4-Nitropyridine N-oxide

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Names

[ CAS No. ]:
1124-33-0

[ Name ]:
4-Nitropyridine N-oxide

[Synonym ]:
4-Nitropyridine N-ox
4-Nitropyridine oxide
4-NITRO-N-OXOPYRIDINE
4-nitraminopyridine N-oxide
wellno604aa
Avitrol 100
4-Nitropyridine N-Oxide
MFCD00006206
4-nitropyridine-N-oxide
4-Nitropyridine 1-oxide
EINECS 214-395-4
4-nitropyridine-1-oxide

Chemical & Physical Properties

[ Density]:
1.43 g/cm3

[ Boiling Point ]:
397.2ºC at 760 mmHg

[ Melting Point ]:
159-162 °C(lit.)

[ Molecular Formula ]:
C5H4N2O3

[ Molecular Weight ]:
140.09700

[ Flash Point ]:
194ºC

[ Exact Mass ]:
140.02200

[ PSA ]:
71.28000

[ LogP ]:
1.54650

[ Water Solubility ]:
insoluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UT6380000
CHEMICAL NAME :
Pyridine, 4-nitro-, 1-oxide
CAS REGISTRY NUMBER :
1124-33-0
LAST UPDATED :
199710
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C5-H4-N2-O3
MOLECULAR WEIGHT :
140.11
WISWESSER LINE NOTATION :
T6NJ AO DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
107 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3916 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
360 mg/kg
TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - pig
DOSE/DURATION :
7208 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - pigeon
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - chicken
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
960 mg/kg/15W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - hamster Cells - not otherwise specified
DOSE/DURATION :
50 umol/L
REFERENCE :
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 229,416,1971

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R36/37/38;R40

[ Safety Phrases ]:
S26-S45-S37/39-S28A

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
UT6380000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29333999

Synthetic Route

Precursor & DownStream

Precursor

  • pyridine oxide
  • 1-oxidopyridin-1-ium,hydrochloride
  • 4-Nitropyridine
  • Sulfuric acid
  • nitric acid

DownStream

  • 4-ethoxypyridine
  • 4-Pyridinol, 3-nitro-,1-oxide
  • 3-Bromo-4-pyridinol
  • Pyridine, 4-ethoxy-,1-oxide
  • 4-Nitro-2,2'-bipyridine-N-oxide
  • 2,2'-bipyridin-4-amine
  • 4-AMINOPYRIDINE
  • 4-Aminopyridine N-Oxide
  • 3-Amino-4-nitropyridine N-oxide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

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PLoS ONE 10 , e0132791, (2015)

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PLoS ONE 8(12) , e83564, (2013)

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Facile one-pot direct arylation and alkylation of nitropyridine N-oxides with Grignard reagents.

Org. Lett. 13(22) , 6102-5, (2011)

Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurre...


More Articles


Related Compounds

  • 4-Nitropyridine N-oxide
  • 4-Nitropyridine N-oxide-d4
  • 3-iodo-4-nitropyridine N-oxide
  • 2-Bromo-4-nitropyridine N-Oxide
  • 3-ethyl-4-nitropyridine N-oxide
  • 2-ethyl-4-nitropyridine N-oxide
  • (4-((4-Chlorophenyl)amino)-6-fluoroquinolin-3-yl)(piperidin-1-yl)methanone
  • 6-fluoro-N-(2-fluorophenyl)-3-(piperidin-1-ylcarbonyl)quinolin-4-amine
  • (6-Fluoro-4-((3-fluorophenyl)amino)quinolin-3-yl)(piperidin-1-yl)methanone
  • (6-Fluoro-4-((4-fluorophenyl)amino)quinolin-3-yl)(piperidin-1-yl)methanone
  • (6-Fluoro-4-((3-methoxyphenyl)amino)quinolin-3-yl)(piperidin-1-yl)methanone
  • (6-Fluoro-4-((4-methoxyphenyl)amino)quinolin-3-yl)(piperidin-1-yl)methanone
  • (4-((4-Ethylphenyl)amino)-6-fluoroquinolin-3-yl)(piperidin-1-yl)methanone
  • (4-((3,4-Dimethylphenyl)amino)-6-fluoroquinolin-3-yl)(piperidin-1-yl)methanone
  • (4-((3,5-Dimethylphenyl)amino)-6-fluoroquinolin-3-yl)(piperidin-1-yl)methanone
  • (4-((2,4-Dimethylphenyl)amino)-6-fluoroquinolin-3-yl)(piperidin-1-yl)methanone
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