4-Nitropyridine N-oxide

Suppliers

Names

[ Name ]:
4-Nitropyridine N-oxide

[Synonym ]:
4-Nitropyridine N-ox
4-Nitropyridine oxide
4-NITRO-N-OXOPYRIDINE
4-nitraminopyridine N-oxide
wellno604aa
Avitrol 100
4-Nitropyridine N-Oxide
MFCD00006206
4-nitropyridine-N-oxide
4-Nitropyridine 1-oxide
EINECS 214-395-4
4-nitropyridine-1-oxide

Chemical & Physical Properties

[ Density]:
1.43 g/cm3

[ Boiling Point ]:
397.2ºC at 760 mmHg

[ Melting Point ]:
159-162 °C(lit.)

[ Molecular Formula ]:
C₅H₄N₂O₃

[ Molecular Weight ]:
140.09700

[ Flash Point ]:
194ºC

[ Exact Mass ]:
140.02200

[ PSA ]:
71.28000

[ LogP ]:
1.54650

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT6380000

CHEMICAL NAME :: Pyridine, 4-nitro-, 1-oxide

CAS REGISTRY NUMBER :: 1124-33-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C5-H4-N2-O3

MOLECULAR WEIGHT :: 140.11

WISWESSER LINE NOTATION :: T6NJ AO DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3916 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 7208 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 20 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 960 mg/kg/15W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - hamster Cells - not otherwise specified

DOSE/DURATION :: 50 umol/L

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 229,416,1971

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R36/37/38;R40

[ Safety Phrases ]:
S26-S45-S37/39-S28A

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
UT6380000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29333999

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

pyridine oxide
1-oxidopyridin-1-ium,hydrochloride
4-Nitropyridine
Sulfuric acid
nitric acid

DownStream

4-ethoxypyridine
4-Pyridinol, 3-nitro-,1-oxide
3-Bromo-4-pyridinol
Pyridine, 4-ethoxy-,1-oxide
4-Nitro-2,2'-bipyridine-N-oxide
2,2'-bipyridin-4-amine
4-AMINOPYRIDINE
4-Aminopyridine N-Oxide
3-Amino-4-nitropyridine N-oxide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pseudomonas aeruginosa Biofilm Formation and Persistence, along with the Production of Quorum Sensing-Dependent Virulence Factors, Are Disrupted by a Triterpenoid Coumarate Ester Isolated from Dalbergia trichocarpa, a Tropical Legume.

PLoS ONE 10 , e0132791, (2015)

Recently, extracts of Dalbergia trichocarpa bark have been shown to disrupt P. aeruginosa PAO1 quorum sensing (QS) mechanisms, which are key regulators of virulence factor expression and implicated in...

At a supra-physiological concentration, human sexual hormones act as quorum-sensing inhibitors.

PLoS ONE 8(12) , e83564, (2013)

N-acylhomoserine lactone (AHL)-mediated quorum-sensing (QS) regulates virulence functions in plant and animal pathogens such as Agrobacterium tumefaciens and Pseudomonas aeruginosa. A chemolibrary of ...

Facile one-pot direct arylation and alkylation of nitropyridine N-oxides with Grignard reagents.

Org. Lett. 13(22) , 6102-5, (2011)

Facile arylation and alkylation of nitropyridine N-oxides were developed through the reactions of Grignard reagents with nitropyridine N-oxides. For the same 4-nitropyridine N-oxide, arylation occurre...

4-Nitropyridine N-oxide
4-Nitropyridine N-oxide-d4
3-iodo-4-nitropyridine N-oxide
2-Bromo-4-nitropyridine N-Oxide
3-ethyl-4-nitropyridine N-oxide
2-ethyl-4-nitropyridine N-oxide
6-[4-[4-bromo-6-(trifluoromethyl)-1H-benzimidazol-2-yl]piperazin-1-yl]quinoline
3-Amino-4-(2-hydroxyethanesulfonyl)benzene-1-sulfonamide
Ethyl 2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-4-methylpyrimidine-5-carboxylate
(2Z)-2-(4-chlorobenzylidene)-6-{[(2E)-3-phenylprop-2-en-1-yl]oxy}-1-benzofuran-3(2H)-one
3-(2-methoxyphenyl)-2-methyl-9-(pyridin-4-ylmethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one
8-(2-((2-fluorophenyl)amino)ethyl)-1,3,7-trimethyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione
(Z)-3-oxo-2-(thiophen-2-ylmethylene)-2,3-dihydrobenzofuran-6-yl cyclohexanecarboxylate
(1E)-(8,8-dimethyl-2,3,9,10-tetrahydro-8H-cyclopenta[c]pyrano[3,2-g]chromen-4(1H)-ylidene)hydrazine
(2Z)-2-(biphenyl-4-ylmethylidene)-7-[(diethylamino)methyl]-6-hydroxy-1-benzofuran-3(2H)-one
(1R)-1-(3-nitrophenyl)propan-1-ol

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