Z-Gly-OH

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Names

[ CAS No. ]:
1138-80-3

[ Name ]:
Z-Gly-OH

[Synonym ]:
Cbz-Gly-OH
CBZ-GLYCINE
QV1MVO1R
N-[(Benzyloxy)carbonyl]glycine
N-Carbobenzoxyglycine
Z-GLY-OH
CBZ-GLY
N-Carbobenzyloxyglycine
Z-GLYCINE
Glycine, N-[(phenylmethoxy)carbonyl]-
z-gly
benzyloxycarbonylaminomethylcarboxylic acid
EINECS 214-516-0
MFCD00002691
N-Gly-OH
N-Cbz-glycine
Carbobenzyloxyglycine
{[(Benzyloxy)carbonyl]amino}acetic acid
Benzyloxycarbonylglycine
Benzyloxycarbonyl-glycine

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
424.0±38.0 °C at 760 mmHg

[ Melting Point ]:
118-122 °C(lit.)

[ Molecular Formula ]:
C10H11NO4

[ Molecular Weight ]:
209.199

[ Flash Point ]:
210.2±26.8 °C

[ Exact Mass ]:
209.068802

[ PSA ]:
75.63000

[ LogP ]:
1.37

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.554

[ Water Solubility ]:
methanol: 0.1 g/mL, clear

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MB9129000
CHEMICAL NAME :
Glycine, N-carboxy-, N-benzyl ester
CAS REGISTRY NUMBER :
1138-80-3
BEILSTEIN REFERENCE NO. :
0526877
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C10-H11-N-O4
MOLECULAR WEIGHT :
209.22
WISWESSER LINE NOTATION :
QVN1R&1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
380 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 70,60,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 70,60,1981

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R62

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
MB9129000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Benzyl chloroformate
  • Glycine
  • Benzyl N-(2-Hydroxyethyl)Carbamate
  • Z-Gly-NHNHPh
  • N-Cbz-glycine Ethyl Ester
  • N-(Benzyloxycarbonyl)glycine tert-butyl ester
  • benzyl N-benzyloxycarbonylglycinate

DownStream

  • Benzyl (cyanomethyl)carbamate
  • benzyl N-(2-chloro-2-oxoethyl)carbamate
  • L-Phenylalanine,N-[N-[(phenylmethoxy)carbonyl]glycyl]-, pentachlorophenyl ester (9CI)
  • z-gly-nh2
  • Z-Sar-OH
  • BENZYL2-AMINOACETATEHYDROCHLORIDE
  • benzyl 2-[(2-phenylmethoxycarbonylaminoacetyl)amino]acetate
  • L-Phenylalanine,N-[N-[(phenylmethoxy)carbonyl]glycyl]-, hydrazide (9CI)
  • BENZYL (2-(METHYLAMINO)-2-OXOETHYL)CARBAMATE
  • Benzyl bromide

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Anticonvulsant activities of N-benzyloxycarbonylglycine after parenteral administration.

Neuroreport 5(7) , 777-80, (1994)

Although glycine does not cross easily the blood-brain barrier, it exhibits at very high doses (10-40 mmol kg-1) a modest anticonvulsant activity. In this study, carbamate derivatives--N-benzyloxycarb...

Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

Bioorg. Med. Chem. 16 , 10061-74, (2008)

Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of ...

Synthesis and anticonvulsant activity of N-benzyloxycarbonyl-amino acid prodrugs of phenytoin.

J. Pharm. Pharmacol. 51 , 549-553, (1999)

Glycine, which has weak anticonvulsant properties, has been shown to potentiate the activity of several antiepileptic drugs but not phenytoin. Recently, studies have shown that N-(benzyloxycarbonyl)gl...


More Articles

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  • 2-((1-Cyanocyclopentyl)amino)-2-oxoethyl 2-(1,3-dioxoisoindolin-2-yl)-4-(methylthio)butanoate
  • 2-Hydroxy-2-(2-phenoxyphenyl)acetic acid
  • 2-(3-Amino-2-oxopiperidin-1-yl)acetic acid;hydrochloride
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