EMD 386088 hydrochloride

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Names

[ CAS No. ]:
1171123-46-8

[ Name ]:
EMD 386088 hydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C14H16Cl2N2

[ Molecular Weight ]:
283.19600

[ Exact Mass ]:
282.06900

[ PSA ]:
27.82000

[ LogP ]:
4.63720

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Excess of serotonin affects neocortical pyramidal neuron migration.

Transl. Psychiatry 1 , e47, (2011)

The serotonin transporter (SERT) is a key molecule involved in the homeostasis of extracellular levels of serotonin and is regulated developmentally. Genetic deletion of SERT in rodents increases extr...

5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.

Br. J. Pharmacol. 167(2) , 436-49, (2012)

5-HT(6) receptors are abundant in the hippocampus, nucleus accumbens and striatum, supporting their role in learning and memory. Selective 5-HT(6) receptor antagonists produce pro-cognitive effects in...

The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.

Psychopharmacology 217(3) , 411-8, (2011)

Preclinical data suggest a possible role for 5-HT6 receptors in depression and anxiety. However, the results of pharmacological studies are equivocal since both blockade and stimulation of 5-HT6 recep...


More Articles

Related Compounds

  • EMD 386088 HYDROCHLORIDE
  • EMD 281014 hydrochloride
  • tert-butyl N-[1-[[2-[[5-[[1-[(6-amino-2-methylpyrimidin-4-yl)methylamino]-3-methyl-1-oxopentan-2-yl]amino]-1-cyclohexyl-3-hydroxy-5-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(2,6-ditritiophenyl)-1-oxopropan-2-yl]carbamate
  • Pramiverin HCl
  • rac Clobenzorex Hydrochloride
  • Ethyl tryptophanate hydrochloride (1:1)
  • Methyl 4-{[(4-chloro-2-fluorophenyl)carbamoyl]methoxy}-6,7-dimethoxyquinoline-2-carboxylate
  • Methyl 4-(2-((3-ethylphenyl)amino)-2-oxoethoxy)-6,7-dimethoxyquinoline-2-carboxylate
  • Methyl 6,7-dimethoxy-4-(2-oxo-2-(phenylamino)ethoxy)quinoline-2-carboxylate
  • Methyl 4-{[(3-chloro-2-methylphenyl)carbamoyl]methoxy}-6,7-dimethoxyquinoline-2-carboxylate
  • Methyl 4-(2-((4-fluorobenzyl)amino)-2-oxoethoxy)-6,7-dimethoxyquinoline-2-carboxylate
  • Methyl 4-{[(2,5-difluorophenyl)carbamoyl]methoxy}-6,7-dimethoxyquinoline-2-carboxylate
  • Methyl 4-({[(4-chlorophenyl)methyl]carbamoyl}methoxy)-6,7-dimethoxyquinoline-2-carboxylate
  • Methyl 4-{[(2,3-dihydro-1,4-benzodioxin-6-YL)carbamoyl]methoxy}-6,7-dimethoxyquinoline-2-carboxylate
  • Methyl 6,7-dimethoxy-4-[(2-methylphenyl)methoxy]quinoline-2-carboxylate
  • Methyl 4-[(3-fluorophenyl)methoxy]-6,7-dimethoxyquinoline-2-carboxylate
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