EMD 386088 hydrochloride

Modify Date: 2024-01-08 14:19:45

EMD 386088 hydrochloride Structure
EMD 386088 hydrochloride structure
Common Name EMD 386088 hydrochloride
CAS Number 1171123-46-8 Molecular Weight 283.19600
Density N/A Boiling Point N/A
Molecular Formula C14H16Cl2N2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS06
GHS06
Signal Word Danger

 Use of EMD 386088 hydrochloride


EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induces cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3].

 Names

Name 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole,hydrochloride

 EMD 386088 hydrochloride Biological Activity

Description EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induces cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3].
Related Catalog
Target

5-HT6 Receptor

In Vitro EMD386088 (1, 10, 60 μM; 0-18 h) induces cell death in a dose- and time- dependent manner[1]. EMD386088 (1, 10, 60 μM) regulates the activity of ERK1/2 in a 5-HT6R-dependent and 5-HT6R–independent manner[1]. Cell Viability Assay[1] Cell Line: HEK/HA-5-HT6R, native HEK293 cells Concentration: 1, 10, 60 μM Incubation Time: 0-18 h Result: Induced cell death in HEK293 cells stably expressing HA-5-HT6R (HEK/HA-5-HT6R) and in native HEK293 cells in a dose- and time- dependent manner. Western Blot Analysis[1] Cell Line: HEK/HA-5-HT6R, native HEK293 cells Concentration: 1, 10, 60 μM Incubation Time: 0-18 h Result: Led to the activation of ERK1/2 at 0-30 μM, retarded ERK1/2 activation at a high dose of 60 μM in HEK/HA-5-HT6R cells.
In Vivo EMD386088 (1, 5, 10 mg/kg) impairs both short-term memory (STM) and long-term memory (LTM) at 5 mg/kg, but produces no significant effects at 10 mg/kg in male Wistar rats[2]. EMD386088 (0, 2, 4 mg/kg) significantly impairs spontaneous alternation performancein at 2 mg/kg, but the high dose of 4 mg/kg dose not reach significance in C57BL/6J mice[3].
References

[1]. Yun HM, et al. 5-HT6 receptor ligands, EMD386088 and SB258585, differentially regulate 5-HT6 receptor-independent events. Toxicol In Vitro. 2011 Dec;25(8):2035-40.

[2]. Meneses A, et al. The effects of the 5-HT(6) receptor agonist EMD and the 5-HT(7) receptor agonist AS19 on memory formation. Behav Brain Res. 2008 Dec 16;195(1):112-9.

[3]. Amodeo DA, et al. 5-HT6 receptor agonist EMD386088 impairs behavioral flexibility and working memory. Behav Brain Res. 2018 Sep 3;349:8-15.

 Chemical & Physical Properties

Molecular Formula C14H16Cl2N2
Molecular Weight 283.19600
Exact Mass 282.06900
PSA 27.82000
LogP 4.63720

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
RIDADR UN 2811 6.1 / PGIII

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