EMD 386088 hydrochloride
EMD 386088 hydrochloride structure
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Common Name | EMD 386088 hydrochloride | ||
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| CAS Number | 1171123-46-8 | Molecular Weight | 283.19600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H16Cl2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of EMD 386088 hydrochlorideEMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induces cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3]. |
| Name | 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole,hydrochloride |
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| Description | EMD386088 is a potent serotonin 6 receptor (5-HT6R) agonist. EMD386088 induces cell death. EMD386088 regulates the activity of ERK1/2. EMD386088 has the potential for the research of alzheimer's disease (AD) and schizophrenia[1][2][3]. |
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| Related Catalog | |
| Target |
5-HT6 Receptor |
| In Vitro | EMD386088 (1, 10, 60 μM; 0-18 h) induces cell death in a dose- and time- dependent manner[1]. EMD386088 (1, 10, 60 μM) regulates the activity of ERK1/2 in a 5-HT6R-dependent and 5-HT6R–independent manner[1]. Cell Viability Assay[1] Cell Line: HEK/HA-5-HT6R, native HEK293 cells Concentration: 1, 10, 60 μM Incubation Time: 0-18 h Result: Induced cell death in HEK293 cells stably expressing HA-5-HT6R (HEK/HA-5-HT6R) and in native HEK293 cells in a dose- and time- dependent manner. Western Blot Analysis[1] Cell Line: HEK/HA-5-HT6R, native HEK293 cells Concentration: 1, 10, 60 μM Incubation Time: 0-18 h Result: Led to the activation of ERK1/2 at 0-30 μM, retarded ERK1/2 activation at a high dose of 60 μM in HEK/HA-5-HT6R cells. |
| In Vivo | EMD386088 (1, 5, 10 mg/kg) impairs both short-term memory (STM) and long-term memory (LTM) at 5 mg/kg, but produces no significant effects at 10 mg/kg in male Wistar rats[2]. EMD386088 (0, 2, 4 mg/kg) significantly impairs spontaneous alternation performancein at 2 mg/kg, but the high dose of 4 mg/kg dose not reach significance in C57BL/6J mice[3]. |
| References |
| Molecular Formula | C14H16Cl2N2 |
|---|---|
| Molecular Weight | 283.19600 |
| Exact Mass | 282.06900 |
| PSA | 27.82000 |
| LogP | 4.63720 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
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Excess of serotonin affects neocortical pyramidal neuron migration.
Transl. Psychiatry 1 , e47, (2011) The serotonin transporter (SERT) is a key molecule involved in the homeostasis of extracellular levels of serotonin and is regulated developmentally. Genetic deletion of SERT in rodents increases extr... |
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5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.
Br. J. Pharmacol. 167(2) , 436-49, (2012) 5-HT(6) receptors are abundant in the hippocampus, nucleus accumbens and striatum, supporting their role in learning and memory. Selective 5-HT(6) receptor antagonists produce pro-cognitive effects in... |
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The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.
Psychopharmacology 217(3) , 411-8, (2011) Preclinical data suggest a possible role for 5-HT6 receptors in depression and anxiety. However, the results of pharmacological studies are equivocal since both blockade and stimulation of 5-HT6 recep... |