EMD 386088 hydrochloride
EMD 386088 hydrochloride structure
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Common Name | EMD 386088 hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 1171123-46-8 | Molecular Weight | 283.19600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H16Cl2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Excess of serotonin affects neocortical pyramidal neuron migration.
Transl. Psychiatry 1 , e47, (2011) The serotonin transporter (SERT) is a key molecule involved in the homeostasis of extracellular levels of serotonin and is regulated developmentally. Genetic deletion of SERT in rodents increases extracellular levels of serotonin and affects cellular processe... |
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5-HT(6) receptor agonists and antagonists enhance learning and memory in a conditioned emotion response paradigm by modulation of cholinergic and glutamatergic mechanisms.
Br. J. Pharmacol. 167(2) , 436-49, (2012) 5-HT(6) receptors are abundant in the hippocampus, nucleus accumbens and striatum, supporting their role in learning and memory. Selective 5-HT(6) receptor antagonists produce pro-cognitive effects in several learning and memory paradigms while 5-HT(6) recept... |
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The 5-HT6 receptor agonist EMD 386088 produces antidepressant and anxiolytic effects in rats after intrahippocampal administration.
Psychopharmacology 217(3) , 411-8, (2011) Preclinical data suggest a possible role for 5-HT6 receptors in depression and anxiety. However, the results of pharmacological studies are equivocal since both blockade and stimulation of 5-HT6 receptors may evoke antidepressant- and anxiolytic-like effects.... |