4-(MALEINIMIDO)PHENYL ISOCYANATE

Names

[ Name ]:
4-(MALEINIMIDO)PHENYL ISOCYANATE

[Synonym ]:
4-(Maleinimido)phenyl isocyanate
1-(4-Isocyanatophenyl)-1H-pyrrole-2,5-dione
1-(4-isocyanatophenyl)pyrrole-2,5-dione
1H-Pyrrole-2,5-dione, 1-(4-isocyanatophenyl)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
375.4±25.0 °C at 760 mmHg

[ Melting Point ]:
120-125ºC

[ Molecular Formula ]:
C₁₁H₆N₂O₃

[ Molecular Weight ]:
214.177

[ Flash Point ]:
180.8±23.2 °C

[ Exact Mass ]:
214.037842

[ PSA ]:
66.81000

[ LogP ]:
1.45

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.641

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H312-H315-H317-H319-H332-H334-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

N-(4-(azidocarbonyl)phenyl)maleimide
4-Maleimidobenzoic acid
4-[[(E)-3-carboxyprop-2-enoyl]amino]benzoic acid
4-(2,5-dioxopyrrol-1-yl)benzoyl chloride

DownStream

Articles

p-maleimidophenyl isocyanate: a novel heterobifunctional linker for hydroxyl to thiol coupling.

Bioconjug. Chem. 4 , 212, (1993)

p-Maleimidophenyl isocyanate (PMPI, 1) is a heterobifunctional cross-linking agent useful for thiol to hydroxyl coupling. Several maleimide-activated compounds were prepared and characterized and then...

Cys-93-betabeta-succinimidophenyl polyethylene glycol 2000 hemoglobin A. Intramolecular cross-bridging of hemoglobin outside the central cavity.

J. Biol. Chem. 275 , 5527, (2000)

Bis(maleidophenyl)-PEG2000 (Bis-Mal-PEG2000), a new bifunctional protein cross-linker targeted to sulfhydryl groups, introduces intra-tetrameric cross-links into oxy-HbA in nearly quantitative yields....

Synthesis of enzyme-degradable, peptide-cross-linked dextran hydrogels.

Bioconjug. Chem. 18(3) , 874-85, (2007)

Hydrogels derived from synthetic polymers have been previously engineered to degrade under the activity of matrix metalloproteinases (MMPs). It is believed that these systems can act as extracellular-...

4-(HEPTYLOXY)PHENYL ISOCYANATE
4-(Difluoromethoxy)phenyl isocyanate
4-(trifluoromethylthio)phenyl isocyanate
4-chlorocarbonyloxy-phenyl isocyanate
4-(OCTYLOXY)PHENYL ISOCYANATE
4-(Trifluoromethyl)phenyl isocyanate
N,N-Bis(2-propoxyethyl)benzenemethanamine
(9|A,11|A,16|A)-17-hydroxy-16-methyl-3,20-dioxo-9,11-epoxypregna-1,4-dien-21-yl acetate
tert-Butyl (3S,4S)-3-(hydroxymethyl)-4-isobutylpyrrolidine-1-carboxylate
3-amino-N-cyclopentyl-6-phenyl-2-Pyrazinecarboxamide
4-(5-Formylpyridin-2-yl)benzonitrile
4-[3-(6-Methyl-pyridin-2-yl)-1h-pyrazol-4-yl]-2-methylsulfanyl-pyrimidine
(S)-3-(3-Methoxy-4-methylphenyl)butanoic acid
[(3aS,5S,6aR,8S,9R,9aR,9bR)-8-acetyloxy-5-hydroxy-3,6-dimethylidene-2-oxo-4,5,6a,7,8,9,9a,9b-octahydro-3aH-azuleno[8,7-b]furan-9-yl]methyl acetate
[(3aS,5S,6aR,8S,9R,9aR,9bR)-8-acetyloxy-5-hydroxy-3,6-dimethylidene-2-oxo-4,5,6a,7,8,9,9a,9b-octahydro-3aH-azuleno[8,7-b]furan-9-yl]methyl 3-methylbutanoate
(2-Amino-4-phenylaminomethyl-phenyl)-carbamic acid ethyl ester

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