Aripiprazole

Suppliers

Names

[ Name ]:
Aripiprazole

[Synonym ]:
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
2(1H)-quinolinone, 7-4-4-(2,3-dichlorophenyl)-1-piperazinylbutoxy-3,4-dihydro-
Abilify
2(1H)-Quinolinone, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-
7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone
7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
UNII-82VFR53I78
7-{4-4-(2,3-dichlorophenyl)piperazin-1-ylbutoxy}-3,4-dihydroquinolin-2(1H)-one
Aripiprazole
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
EINECS 200-835-2
MFCD00892072

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
646.2±55.0 °C at 760 mmHg

[ Melting Point ]:
139°C

[ Molecular Formula ]:
C₂₃H₂₇Cl₂N₃O₂

[ Molecular Weight ]:
448.385

[ Flash Point ]:
344.6±31.5 °C

[ Exact Mass ]:
447.148041

[ PSA ]:
44.81000

[ LogP ]:
5.59

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.593

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311 + H331-H370

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P261-P280-P302 + P352 + P312-P304 + P340 + P312-P403 + P233

[ Hazard Codes ]:
F,Xn

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 1993C 3 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

7-(4-Chlorobutoxy)-3,4-dihydro-2(1H)-quinolinone
1-(2,3-DICHLOROPHENYL)PIPERAZINE
7-(allyloxy)-3,4-dihydro-2(1H)-quinolinone
carbon monoxide
7-(4-Brombutoxy)-3,4-dihydrochinolin-2(1H)-on
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]-2-butenyloxy]-3,4-dihydro-1H-quinoline-2-one

DownStream

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range.

J. Pharmacol. Sci. 127(3) , 326-31, (2015)

Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human stud...

In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.

J. Pharmacol. Exp. Ther. 352(3) , 471-9, (2015)

Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and select...

The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.

Drug Test. Anal. 7 , 502-11, (2015)

Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alte...