Aripiprazole
Aripiprazole structure
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Common Name | Aripiprazole | ||
|---|---|---|---|---|
| CAS Number | 129722-12-9 | Molecular Weight | 448.385 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 646.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H27Cl2N3O2 | Melting Point | 139°C | |
| MSDS | Chinese USA | Flash Point | 344.6±31.5 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range.
J. Pharmacol. Sci. 127(3) , 326-31, (2015) Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 re... |
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In vivo pharmacological characterization of TAK-063, a potent and selective phosphodiesterase 10A inhibitor with antipsychotic-like activity in rodents.
J. Pharmacol. Exp. Ther. 352(3) , 471-9, (2015) Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. We evaluated the in vivo pharmacological profile of a potent and selective PDE10A inhibitor, TAK-063 (1-[2-fluoro-4-(1H-pyrazol-1-... |
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The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.
Drug Test. Anal. 7 , 502-11, (2015) Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has conse... |
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MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol.
Behav. Pharmacol. 26 , 748-65, (2015) Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, social withdrawal belongs to the category of negative symptoms and is associated with deficits in the cognitive domain. Here, we used the N-methyl-D-as... |
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A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity.
Sci. Transl. Med. 7 , 290ra89, (2015) Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola viruses, and recent events have demonstrated an urgent need for rapid discovery of new treatments. Repurposing approved drugs for emerging infections remains a critical ... |
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Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain.
Psychiatry Res. 225(3) , 347-54, (2015) Neuregulin-1 (NRG1) and ErbB4 genes have been identified as candidate genes for schizophrenia. Post-mortem studies indicated that NRG1-ErbB4 signalling is impaired in schizophrenia subjects. This study investigated whether short- or long-term antipsychotic tr... |
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Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.
J. Pharmacol. Exp. Ther. 352(3) , 480-93, (2015) G protein-coupled receptors (GPCRs) often activate multiple signaling pathways, and ligands may evoke functional responses through individual pathways. These unique responses provide opportunities for biased or functionally selective ligands to preferentially... |
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Aripiprazole versus other atypical antipsychotics for schizophrenia.
Cochrane Database Syst. Rev. 2 , CD006569, (2013) In most western industrialised countries, second generation (atypical) antipsychotics are recommended as first line drug treatments for people with schizophrenia. In this review we specifically examine how the efficacy and tolerability of one such agent - ari... |
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Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator.
J. Pharmacol. Exp. Ther. 350(3) , 605-14, (2014) Brexpiprazole (OPC-34712, 7-{4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy}quinolin-2(1H)-one) is a novel serotonin-dopamine activity modulator with partial agonist activity at serotonin 1A (5-HT1A) and D2/3 receptors, combined with potent antagonist effec... |
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Quality of life in children and adolescents with autism spectrum disorders: what is known about the effects of pharmacotherapy?
Paediatr. Drugs 16(2) , 123-8, (2014) A diagnosis of autistic spectrum disorder (ASD), now estimated to affect one in 88 children, requires deficits in social communication and interactions, and restricted interests and/or repetitive behaviors. Almost all children with ASD have deficits in adapti... |