Comins' Reagent

Suppliers

Names

[ CAS No. ]:
145100-51-2

[ Name ]:
Comins' Reagent

[Synonym ]:
2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
2-(N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulf
N-(5-Chloro-2-pyridyl)triflimide
MFCD00191833
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Comins Triflating
2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine
Comins' Reagent
Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-
N-(5-Chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Boiling Point ]:
358.3±52.0 °C at 760 mmHg

[ Melting Point ]:
45-47 °C(lit.)

[ Molecular Formula ]:
C7H3ClF6N2O4S2

[ Molecular Weight ]:
392.683

[ Flash Point ]:
170.5±30.7 °C

[ Exact Mass ]:
391.912689

[ PSA ]:
101.17000

[ LogP ]:
2.68

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Storage condition ]:
Keep Cold

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Amino-5-chloropyridine
  • triflic anhydride

DownStream

  • ETHYL 4-((5,5-DIMETHYL-8-(((TRIFLUOROMETHYL)SULFONYL)OXY)-5,6-DIHYDRONAPHTHALEN-2-YL)ETHYNYL)BENZOATE
  • 3,6-dihydro-2H-thiopyran-4-yl trifluoromethanesulfonate
  • 3,6-Dihydro-2H-pyran-4-yl trifluoromethanesulfonate
  • 8-BOC-3-(TRIFLUOROMETHYLSULFONYLOXY)-8-AZABICYCLO[3.2.1]OCT-3-ENE
  • ETHYL 4-(((TRIFLUOROMETHYL)SULFONYL)OXY)CYCLOHEX-3-ENECARBOXYLATE
  • 1-(tert-Butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl trifluoromethanesulfonate
  • 1,4-Dioxaspiro[4.5]dec-7-en-8-yl trifluoromethanesulfonate
  • ETHYL2-(TRIFLUOROMETHYLSULFONYLOXY)-1-CYCLOHENXENE-1-CARBOXYLATE
  • ethyl 3-(trifluoromethylsulfonyloxy)but-2-enoate
  • tert-butyl 5-(trifluoromethylsulfonyloxy)-3,6-dihydro-2H-pyridine-1-carboxylate

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide.

Angew. Chem. Int. Ed. Engl. 53(10) , 2692-5, (2014)

Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer dru...

Tetrahedron Lett. 33 , 6299, (1992)

Tetrahedron Lett. 44 , 9185, (2003)


More Articles

Related Compounds

  • Comins' reagent
  • Eschenmoser's reagent
  • AMINOMETHYLATING REAGENT A
  • Cornforth reagent
  • Hendrickson's reagent
  • Stang's reagent
  • Ethyl 4-{[(3,5-dimethoxyphenyl)carbamoyl]methoxy}-1-(2-methylphenyl)-6-oxo-1,6-dihydropyridazine-3-carboxylate
  • N-(3-(benzo[d]thiazol-2-yl)-4,5-dimethylthiophen-2-yl)-2-(methylsulfonyl)benzamide
  • N2-(3,5-dichlorophenyl)-N4-(4-ethylphenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
  • N2-(4-fluorophenyl)-6-morpholino-N4-(m-tolyl)-1,3,5-triazine-2,4-diamine hydrochloride
  • 4-Methyltetrahydro-2H-thiopyran-4-amine
  • 6-Chloro-3-(3-chloropropyl)-2-benzothiazolone
  • 3-Acetyl-5-chloro-2-thiophenesulfenamide
  • 3-(Aminomethyl)-2,3-dihydro-2,5,9-trimethyl-7H-furo[3,2-g][1]benzopyran-7-one
  • O-propylserine
  • 8-(hydroxymethyl)-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
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