Comins' Reagent

Comins' Reagent Structure
Comins' Reagent structure
Common Name Comins' Reagent
CAS Number 145100-51-2 Molecular Weight 392.683
Density 1.9±0.1 g/cm3 Boiling Point 358.3±52.0 °C at 760 mmHg
Molecular Formula C7H3ClF6N2O4S2 Melting Point 45-47 °C(lit.)
MSDS Chinese USA Flash Point 170.5±30.7 °C
Symbol GHS07
GHS07
Signal Word Warning

Total synthesis of the antimitotic marine macrolide (-)-leiodermatolide.

Angew. Chem. Int. Ed. Engl. 53(10) , 2692-5, (2014)

Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer drug discovery. In pursuit of a sustainable supply, we report ...

Tetrahedron Lett. 33 , 6299, (1992)

Tetrahedron Lett. 44 , 9185, (2003)

Synthesis 4 , 588, (2000)