Comins' Reagent

Modify Date: 2025-08-20 17:04:47

Comins' Reagent Structure
Comins' Reagent structure
Common Name Comins' Reagent
CAS Number 145100-51-2 Molecular Weight 392.683
Density 1.9±0.1 g/cm3 Boiling Point 358.3±52.0 °C at 760 mmHg
Molecular Formula C7H3ClF6N2O4S2 Melting Point 45-47 °C(lit.)
MSDS Chinese USA Flash Point 170.5±30.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.9±0.1 g/cm3
Boiling Point 358.3±52.0 °C at 760 mmHg
Melting Point 45-47 °C(lit.)
Molecular Formula C7H3ClF6N2O4S2
Molecular Weight 392.683
Flash Point 170.5±30.7 °C
Exact Mass 391.912689
PSA 101.17000
LogP 2.68
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.499
Storage condition Keep Cold

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2935009090

 Synthetic Route

~82%

Comins' Reagent Structure

Comins' Reagent

CAS#:145100-51-2

Literature: Comins, Daniel L.; Dehghani, Ali Tetrahedron Letters, 1992 , vol. 33, # 42 p. 6299 - 6302

 Customs

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

 Articles4

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Leiodermatolide is an antimitotic macrolide isolated from the marine sponge Leiodermatium sp. whose potentially novel tubulin-targeting mechanism of action makes it an exciting lead for anticancer dru...

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 Synonyms

2-[N,N-Bis(trifluoromethanesulfonyl)amino]-5-chloropyridine
N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-(trifluoromethylsulfonyl)methanesulfonamide
N-(5-Chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
2-(N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulf
N-(5-Chloro-2-pyridyl)triflimide
MFCD00191833
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonyl)imide
N-(5-Chloro-2-pyridyl)bis(trifluoromethanesulfonimide)
Comins Triflating
2-[N,N-Bis(Trifluoromethylsulphonyl)amino]-5-chloropyridine
Comins' Reagent
Methanesulfonamide, N-(5-chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]-
N-(5-Chloro-2-pyridinyl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide
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