TRIMETHYLACETIC ANHYDRIDE

Suppliers

Names

[ Name ]:
TRIMETHYLACETIC ANHYDRIDE

[Synonym ]:
Pivalic anhydride
MFCD00008842
2,2-dimethylpropanoyl 2,2-dimethylpropanoate
Trimethylacetic Anhydride
2,2-Dimethylpropionic Anhydride
2,2-Dimethylpropanoic anhydride
2,2-Dimethylpropionic anhydride,Pivalic anhydride
EINECS 216-263-1
PROPANOIC ACID, 2,2-DIMETHYL-, ANHYDRIDE

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
193.0±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₈O₃

[ Molecular Weight ]:
186.248

[ Flash Point ]:
57.2±0.0 °C

[ Exact Mass ]:
186.125595

[ PSA ]:
43.37000

[ LogP ]:
1.97

[ Vapour Pressure ]:
0.5±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.429

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2920 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Pivaloyl chloride
Pivalic acid
Ethoxyethyne
TERT-BUTYLMAGNESIUM CHLORIDE
Benzyl chloroformate
Benzyl alcohol
Dipyridin-2-yl carbonate
thallium(I) 2,2-dimethylpropanoate
2-tert-butyl-4,4-dimethyl-pent-1-en-3-one

DownStream

PhSiFClOC(O)C(CH3)3
Pivaloyl chloride
2,6-Di-tert-butyl-4-methylpyridine
3,4-dimethyl-2,6-diterbutylpyridine
4-ethyl-2,6-diterbutylpyridine
N-Boc-1,5-diaminopentane
2-TERT-BUTYL-PYRIDIN-4-YLAMINE
1-Boc-4-Cyanopiperidine
N-BOC-Pyrrole
Propanoic acid,2,2-dimethyl-, 4-nitrophenyl ester

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Kinetic resolution of racemic 2-hydroxy-γ-butyrolactones by asymmetric esterification using diphenylacetic acid with pivalic anhydride and a chiral acyl-transfer catalyst.

Org. Lett. 15(6) , 1170-3, (2013)

Various optically active 2-hydroxy-γ-butyrolactone derivatives are produced via the kinetic resolution of racemic 2-hydroxy-γ-butyrolactones with diphenylacetic acid using pivalic anhydride and (R)-be...

The concept of superactive esters. Could peptide synthesis be improved by inventing superactive esters?

Int. J. Pept. Protein Res. 43 , 312, (1994)

According to the concept presented, esters forming an amide (peptide) bond by the mechanism SN#DN or SN#*DN involving fast decay of the tetrahedral intermediate may behave as 'superactive acylating re...

Observation and elimination of N-acetylation of oligonucleotides prepared using fast-deprotecting phosphoramidites and ultra-mild deprotection.

Bioorg. Med. Chem. Lett. 11(9) , 1105-1107, (2001)

Commercially available 'fast-deprotecting' phosphoramidites are useful for synthesizing oligonucleotides containing alkali-sensitive nucleotides. However, N-acetylated oligonucleotides were observed d...