6-Chloro-1H-indole

Names

[ Name ]:
6-Chloro-1H-indole

[Synonym ]:
6-chloro indole
1H-Indole, 6-chloro-
MFCD00005681
6-Chloroindole
6-Cl-indole
EINECS 241-449-4
1H-Indole,6-chloro
6-chlorolindole
6-Chloro-1H-indole

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
293.0±13.0 °C at 760 mmHg

[ Melting Point ]:
87-90 °C(lit.)

[ Molecular Formula ]:
C₈H₆ClN

[ Molecular Weight ]:
151.59

[ Flash Point ]:
158.9±5.4 °C

[ Exact Mass ]:
151.018875

[ PSA ]:
15.79000

[ LogP ]:
2.74

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.688

[ Stability ]:
Store in Refrigerator

[ Water Solubility ]:
slightly soluble

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Pyrrolidine
4,2-chloronitrotoluene
N,N-Dimethylformamide dimethyl acetal
1-amino-5-chloro-2-(β-hydroxyethyl)benzene
5-chloro-trans-2-[β-(dimethylamino)vinyl]-nitrobenzene
6-chloro-1-methylsulfonylindole
Benzene,4-chloro-2-nitro-1-(2-nitroethenyl)-
1-(2-bromo-2-chloroethyl)-4-chloro-2-nitrobenzene

DownStream

6-Phenyl-1H-indole
6-Chloro-L-tryptophan
1H-Indole-3-methanamine,6-chloro-N,N-dimethyl-
N-Acetyl 6-Chlorotryptophan
7-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
6-CHLORO-3-(1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1H-INDOLE
6-Chloroindole-3-acetic acid
6-Chloro-2,3-dihydro-1H-indole
6-Chloro-1H-indole-3-carbaldehyde
6-Chloro-1H-indole-3-carboxylic acid

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

J. Enzyme Inhib. Med. Chem. 29(6) , 846-67, (2014)

Because of the pivotal role of cyclooxygenase (COX) in the inflammatory processes, non-steroidal anti-inflammatory drugs (NSAIDs) that suppress COX activities have been used clinically for the treatme...

Toward prediction of alkane/water partition coefficients.

J. Med. Chem. 51 , 3720-30, (2008)

Partition coefficients were measured for 47 compounds in the hexadecane/water ( P hxd) and 1-octanol/water ( P oct) systems. Some types of hydrogen bond acceptor presented by these compounds to the pa...

Production of substituted L-tryptophans by fermentation.

Appl. Microbiol. 21(5) , 841-3, (1971)

Claviceps purpurea has been shown to produce extracellular l-tryptophan from indole in stirred fermentors. The substrate specificity of this conversion was investigated by using substituted indoles, a...

1-BOC-6-CHLORO-1H-INDOLE
5-Bromo-6-chloro-1H-indole
4-Bromo-6-chloro-1H-indole
3-bromo-6-chloro-1H-indole
6-chloro-1H-indole-2,3-dione
6-Chloro-1H-indole-3-ethanamine
ethyl 2-({[4-(acetylamino)-1H-indol-1-yl]acetyl}amino)-4-methyl-1,3-thiazole-5-carboxylate
N-(6-methoxypyridin-3-yl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)acetamide
N-(1H-indol-6-yl)-1-[2-(2-methoxyphenyl)ethyl]-5-oxopyrrolidine-3-carboxamide
N-(1-cyanocyclopentyl)-2-(2,4-dichlorophenyl)-1,3-thiazole-4-carboxamide
N-(1-cyanocyclobutyl)-3-(2,3-dihydro-1H-indene-5-sulfonyl)-N-methylpropanamide
N-(1-cyanocyclobutyl)-N-methyl-2-{[5-(naphthalen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamide
N-(1-cyanocyclobutyl)-2-cyclohexylidene-N-methylacetamide
2-(4-acetamido-1H-indol-1-yl)-N-(5-isobutyl-1,3,4-thiadiazol-2-yl)acetamide
2-(6,7-dimethoxy-2-methyl-4-oxoquinazolin-3(4H)-yl)-N-(1-methyl-1H-pyrazol-4-yl)acetamide
4-[2-(2,4-Dinitrophenyl)hydrazinylidene]-4,5,6,7-tetrahydro-3-methyl-2-benzofurancarboxylic acid 2-(2-furanylcarbonyl)hydrazide