6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

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Names

[ Name ]:
6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione

[Synonym ]:
6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 6-(chloromethyl)-
6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione
EINECS 242-431-9
6-chloromethylpyrimidine-2,4-dione
6-uracilylmethylchloride
MFCD00466419
6-Chloromethyluracil
6-(Chloromethyl)uracil

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
493.9ºC at 760 mmHg

[ Melting Point ]:
257 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₅ClN₂O₂

[ Molecular Weight ]:
160.558

[ Flash Point ]:
252.5ºC

[ Exact Mass ]:
160.003952

[ PSA ]:
65.72000

[ LogP ]:
0.04

[ Vapour Pressure ]:
2.23E-10mmHg at 25°C

[ Index of Refraction ]:
1.511

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933599090

Precursor & DownStream

Precursor

6-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione
Ethyl 2-Chloroacetoacetate
Urea
6-(CHLOROMETHYL)-2-(METHYLTHIO)PYRIMIDIN-4(3H)-ONE
6-Methyluracil
6-FORMYL-URACIL MONOHYDRATE
Pyridine
4-chloro-3-oxobutanoyl chloride

DownStream

5-bromo-6-(chloromethyl)-1H-pyrimidine-2,4-dione
6-[(tridecylamino)methyl]-1H-pyrimidine-2,4-dione
5-hydroxyimidazolidine-2,4-dione
2,4-Imidazolidinedione, 1-(chloroacetyl)-5-hydroxy- (9CI)
Chloroacetic acid
N-((1,2,3,6-tetrahydro-2,6-dioxopyrimidin-4-yl)Methyl)acetamide
6-(CHLOROMETHYL)-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE
6-[(octadecylamino)methyl]-1H-pyrimidine-2,4-dione
Acetic acid,2-[[(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)methyl]thio]-
4-[(2,6-dioxo-3H-pyrimidin-4-yl)methylamino]benzoic acid

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and enzymatic evaluation of pyridinium-substituted uracil derivatives as novel inhibitors of thymidine phosphorylase.

Bioorg. Med. Chem. 10(3) , 525-30, (2002)

A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the...

Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: discovery of novel orally active inhibitors of human thymidine phosphorylase.

Bioorg. Med. Chem. 12(13) , 3431-41, (2004)

A series of novel 6-methylene-bridged uracil derivatives have been prepared as inhibitors of human thymidine phosphorylase (TP). To enhance the in vivo antitumor activity of fluorinated pyrimidine 2'-...

Syntheses of novel heterocycles as anticancer agents.

Bioorg. Med. Chem. 13(10) , 3513-8, (2005)

Several pteridine analogues 4-13, 23-26 have been synthesized and tested in vitro against three cancer cell lines, MCF7 (breast), NCI-H460 (lung) and SF-268 (CNS). All tested pteridines can serve as n...

5-Chloro-6-(chloromethyl)-2,4(1H,3H)-pyrimidinedione
6-(Chloromethyl)-1,3-bis(4-methoxybenzyl)-2,4(1H,3H)-pyrimidinedione
6-(Aminomethyl)-2,4(1H,3H)-pyrimidinedione
6-Ethoxy-2,4(1H,3H)-pyrimidinedione
6-(Hydroxymethyl)-2,4(1H,3H)-pyrimidinedione
6-(CHLOROMETHYL)-1,3-DIMETHYLPYRIMIDINE-2,4(1H,3H)-DIONE
Allopregnane-3beta,17alpha,20beta-triol 3,20-diacetate
7-Hydroxy-3,4,8-trimethyl-1,2-dihydroquinolin-2-one
3,4,8-Trimethyl-7-(2-propen-1-yloxy)-2(1H)-quinolinone
2-Hydroxy-2-(6-methoxynaphthalen-2-yl)acetonitrile
3-Ethoxy-5-methyl-4-isoxazolecarboxylic acid
(5R,10S)-N-(2-(1H-Imidazol-4-yl)ethyl)-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
N-[(Phenylmethoxy)carbonyl]-L-alanyl-L-valyl-L-alanine methyl ester
2-{[(Benzyloxy)carbonyl]amino}-3-(1,3-thiazol-2-yl)propanoic acid
(2S)-2-{[(benzyloxy)carbonyl]amino}-3-(1,3-thiazol-2-yl)propanoic acid
2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanamido]-2-methylpropanoic acid

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