Tyrphostin A1

Suppliers

Names

[ Name ]:
Tyrphostin A1

[Synonym ]:
AG 9
(4-Methoxybenzylidene)malonitrile
Tyrphostin A1
Tyrphostin 1
2-(4-Methoxybenzylidene)malononitrile
(4-Methoxybenzylidene)malononitrile
2-[(4-methoxyphenyl)methylidene]malononitrile
2-[(4-methoxyphenyl)methylene]malononitrile
p-methoxybenzylidenemalononitrile
(4-methoxyphenylmethylene)methane-1,1-dicarbonitrile
MFCD00019787

Chemical & Physical Properties

[ Density]:
1.169g/cm3

[ Boiling Point ]:
352.4ºC at 760mmHg

[ Melting Point ]:
113-116ºC(lit.)

[ Molecular Formula ]:
C₁₁H₈N₂O

[ Molecular Weight ]:
184.19400

[ Flash Point ]:
148.8ºC

[ Exact Mass ]:
184.06400

[ PSA ]:
56.81000

[ LogP ]:
2.12576

[ Vapour Pressure ]:
3.85E-05mmHg at 25°C

[ Index of Refraction ]:
1.589

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
chloroform: soluble50mg/mL, clear, light yellow

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
36/37

[ RIDADR ]:
UN 3439 6.1/PG III

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ HS Code ]:
2926909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Methoxybenzaldehyde
Malononitrile
(Z)-(4-methoxyphenyl)methylidene-oxido-phenyl-azanium
5-[(4-METHOXYPHENYL)METHYLENE]-2,2-DIMETHYL-1,3-DIOXANE-4,6-DIONE
Dibromomalononitrile
Tetracyanoethylene
N-[(4-methoxyphenyl)methylidene]-4-methylbenzenesulfonamide
3-(4-methoxyphenyl)-2-nitro-1-phenyl-2-propen-1-one
1,2-bis(4-methoxyphenyl)-1,2-Ethanediol
Propionaldehyde

DownStream

2-(4-METHOXYBENZYL)MALONONITRILE
3,5-Diethoxycarbonyl-2,6-dimethylpyridine
1H-Benzimidazole,2-(4-methoxyphenyl)-
1,1,2,2-Cyclopropanetetracarbonitrile,(4-methoxyphenyl)-
2,6-diamino-4-(4-methoxyphenyl)-4H-thiopyran-3,5-dicarbonitrile
5-acetyl-2-amino-4-(4-methoxyphenyl)-6-methyl-4h-pyran-3-carbonitrile
4-Methylanisole
4-Methoxybenzaldehyde

Customs

[ HS Code ]: 2926909090

[ Summary ]:
HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.

J. Med. Chem. 32 , 2344, (1989)

A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the su...

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.

Science 242(4880) , 933-5, (1988)

A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epiderma...

Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.

Nat. Med. 5(1) , 71-7, (1999)

Adeno-associated virus 2 (AAV)-based vectors have gained attention as a potentially useful alternative to the more commonly used retroviral and adenoviral vectors for human gene therapy. Although AAV ...