Tyrphostin A1
Tyrphostin A1 structure
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Common Name | Tyrphostin A1 | ||
|---|---|---|---|---|
| CAS Number | 2826-26-8 | Molecular Weight | 184.19400 | |
| Density | 1.169g/cm3 | Boiling Point | 352.4ºC at 760mmHg | |
| Molecular Formula | C11H8N2O | Melting Point | 113-116ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 148.8ºC | |
Use of Tyrphostin A1Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.IC50 value: Target: IL-12 production inhibitorAddition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM. tyrphostin A1 blocks CD40L-induced translocation of NF-κB to the nucleus, and reduces the activation of IL-12 p40 gene. In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells. In addition, treatment of SJL/J mice with A1 results in attenuation of experimental allergic encephalomyelitis (EAE) [1]. Tyrphostin A1 is a much weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase), and therefore often used to differentiate TK-mediated effects of tyrphostins from other non-specific effects [2]. |
| Name | 2-[(4-methoxyphenyl)methylidene]propanedinitrile |
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| Synonym | More Synonyms |
| Description | Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells.IC50 value: Target: IL-12 production inhibitorAddition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM. tyrphostin A1 blocks CD40L-induced translocation of NF-κB to the nucleus, and reduces the activation of IL-12 p40 gene. In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells. In addition, treatment of SJL/J mice with A1 results in attenuation of experimental allergic encephalomyelitis (EAE) [1]. Tyrphostin A1 is a much weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase), and therefore often used to differentiate TK-mediated effects of tyrphostins from other non-specific effects [2]. |
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| Related Catalog | |
| References |
| Density | 1.169g/cm3 |
|---|---|
| Boiling Point | 352.4ºC at 760mmHg |
| Melting Point | 113-116ºC(lit.) |
| Molecular Formula | C11H8N2O |
| Molecular Weight | 184.19400 |
| Flash Point | 148.8ºC |
| Exact Mass | 184.06400 |
| PSA | 56.81000 |
| LogP | 2.12576 |
| Vapour Pressure | 3.85E-05mmHg at 25°C |
| Index of Refraction | 1.589 |
| Storage condition | 2-8°C |
| Water Solubility | chloroform: soluble50mg/mL, clear, light yellow |
| Precursor 10 | |
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| DownStream 8 | |
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CAS#:104-93-8| HS Code | 2926909090 |
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| Summary | HS:2926909090 other nitrile-function compounds VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
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Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
J. Med. Chem. 32 , 2344, (1989) A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the su... |
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Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.
Science 242(4880) , 933-5, (1988) A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epiderma... |
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Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.
Nat. Med. 5(1) , 71-7, (1999) Adeno-associated virus 2 (AAV)-based vectors have gained attention as a potentially useful alternative to the more commonly used retroviral and adenoviral vectors for human gene therapy. Although AAV ... |
| AG 9 |
| (4-Methoxybenzylidene)malonitrile |
| Tyrphostin A1 |
| Tyrphostin 1 |
| 2-(4-Methoxybenzylidene)malononitrile |
| (4-Methoxybenzylidene)malononitrile |
| 2-[(4-methoxyphenyl)methylidene]malononitrile |
| 2-[(4-methoxyphenyl)methylene]malononitrile |
| p-methoxybenzylidenemalononitrile |
| (4-methoxyphenylmethylene)methane-1,1-dicarbonitrile |
| MFCD00019787 |