Tyrphostin A1
Tyrphostin A1 structure
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Common Name | Tyrphostin A1 | ||
|---|---|---|---|---|
| CAS Number | 2826-26-8 | Molecular Weight | 184.19400 | |
| Density | 1.169g/cm3 | Boiling Point | 352.4ºC at 760mmHg | |
| Molecular Formula | C11H8N2O | Melting Point | 113-116ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 148.8ºC | |
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Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors.
J. Med. Chem. 32 , 2344, (1989) A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These compe... |
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Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors.
Science 242(4880) , 933-5, (1988) A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epidermal growth factor (EGF) receptor kinase domain. These compoun... |
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Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2.
Nat. Med. 5(1) , 71-7, (1999) Adeno-associated virus 2 (AAV)-based vectors have gained attention as a potentially useful alternative to the more commonly used retroviral and adenoviral vectors for human gene therapy. Although AAV uses the ubiquitously expressed cell surface heparan sulfat... |
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Cyclic stretch regulates autocrine IGF-I in vascular smooth muscle cells: implications in vascular hyperplasia.
Am. J. Physiol. 276(4 Pt 1) , E697-705, (1999) Vascular smooth muscle cells (VSMC) subjected to acute or chronic stretch display enhanced growth rates in vitro and in vivo. Clinical examples of vascular hyperplasia (e.g., systolic hypertension and postinjury restenosis) suggest that local insulin-like gro... |
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Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells.
Biochem. Biophys. Res. Commun. 189(3) , 1620-3, (1992) Selective inhibitors of tyrosine kinases, tyrphostin 23 and genistein, produced concentration-dependent inhibition of voltage-operated calcium channel currents in vascular smooth muscle cells isolated from rabbit ear artery. The potency of these two structura... |
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Design, synthesis, antimicrobial evaluation and molecular docking studies of some new thiophene, pyrazole and pyridone derivatives bearing sulfisoxazole moiety.
Eur. J. Med. Chem. 84 , 491-504, (2014) Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. In this context, new functionalized thiophene, acrylamide, arylhydrazone, pyrazole and pyridone derivatives bearing sulfisoxazole moiety were designed, synthesize... |