BTO-1

Names

[ Name ]:
BTO-1

[Synonym ]:
BTO-1
5-cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide
HMS3260F21
HMS3229L17
5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₄N₄O₄S

[ Molecular Weight ]:
264.21700

[ Exact Mass ]:
263.99500

[ PSA ]:
166.40000

[ LogP ]:
2.43208

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

Mol. Cell. 45 , 371-383, (2012)

Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusiv...

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.

Nat. Chem. Biol. 2 , 608-617, (2006)

Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and fo...

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.

Curr. Chem. Genomics 5 , 21-9, (2011)

Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for ...

2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
3-[1-(2,5-dimethylthiophen-3-yl)octadecyl]-4-propan-2-ylideneoxolane-2,5-dione
hex-1-enyl(diphenyl)phosphane
3-(1-aminophenothiazin-10-ium-10-ylidene)phenothiazin-1-amine
triethyl(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9-heptadecafluorodecyl)azanium,chloride
3-(1-thiophen-3-ylpropyl)thiophene
(1-(1-(1H-pyrrol-2-yl)ethyl)pyrrolidin-3-yl)methanol
(1-(1-(1H-pyrrol-2-yl)ethyl)piperidin-4-yl)methanol
(3R)-1-(1-(thiophen-2-yl)ethyl)piperidin-3-ol
(3R)-1-(1-(pyrazin-2-yl)ethyl)piperidin-3-ol
(3R)-1-(1-(thiazol-2-yl)ethyl)piperidin-3-ol
(3S)-1-(1-(pyridin-2-yl)ethyl)piperidin-3-ol
4-((1-(3-chlorobenzoyl)azetidin-3-yl)oxy)-6-methyl-2H-pyran-2-one
Tert-butyl (1-(1-(furan-2-yl)ethyl)piperidin-3-yl)(methyl)carbamate
tert-butyl ((1-(1-(1H-pyrrol-2-yl)ethyl)piperidin-3-yl)methyl)carbamate
Tert-butyl ((1-(1-(furan-2-yl)ethyl)piperidin-3-yl)methyl)carbamate