BTO-1

Names

[ Name ]:
BTO-1

[Synonym ]:
BTO-1
5-cyano-7-nitro-3-oxy-benzothiazole-2-carboxylic acid amide
HMS3260F21
HMS3229L17
5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₄N₄O₄S

[ Molecular Weight ]:
264.21700

[ Exact Mass ]:
263.99500

[ PSA ]:
166.40000

[ LogP ]:
2.43208

[ Storage condition ]:
2-8°C

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H315-H319-H332-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.

Mol. Cell. 45 , 371-383, (2012)

Homologous recombination (HR) plays an important role in the maintenance of genome integrity. HR repairs broken DNA during S and G2 phases of the cell cycle but its regulatory mechanisms remain elusiv...

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.

Nat. Chem. Biol. 2 , 608-617, (2006)

Polo-like kinases (Plks) have several functions in mitotic progression and are upregulated in many tumor types. Small-molecule Plk inhibitors would be valuable as tools for studying Plk biology and fo...

Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.

Curr. Chem. Genomics 5 , 21-9, (2011)

Tumor Necrosis Factor-α (TNF-α), a secreted cytokine, plays an important role in inflammatory diseases and immune disorders, and is a potential target for drug development. The traditional assays for ...

2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
3-[1-(2,5-dimethylthiophen-3-yl)octadecyl]-4-propan-2-ylideneoxolane-2,5-dione
hex-1-enyl(diphenyl)phosphane
3-(1-aminophenothiazin-10-ium-10-ylidene)phenothiazin-1-amine
triethyl(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9-heptadecafluorodecyl)azanium,chloride
3-(1-thiophen-3-ylpropyl)thiophene
3-(4-Bromophenyl)-6-[4-benzylpiperazinyl]pyridazine
ethyl 4-{[5-fluoro-2-(1H-tetrazol-1-yl)phenyl]carbonyl}piperazine-1-carboxylate
N-{4,5-dimethyl-3-[(4-methylphenyl)sulfonyl]-1-(propan-2-yl)-1H-pyrrol-2-yl}-2,2-dimethylpropanamide
2-[(3,4-dimethoxyphenyl)acetyl]-8-fluoro-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
2-[4-(6-bromo-2-oxo-2H-chromen-3-yl)phenoxy]-N-cyclopropylacetamide
1-ethyl-6-methoxy-4-oxo-N-(1,3-thiazol-2-yl)-1,4-dihydroquinoline-3-carboxamide
3-(4-fluorophenyl)-9-propyl-2-(trifluoromethyl)-9,10-dihydrochromeno[8,7-e][1,3]oxazin-4(8H)-one
4,5-dimethoxy-N-{2-[(5-methyl-1,3-thiazol-2-yl)amino]-2-oxoethyl}-1H-indole-2-carboxamide
1-[4-(2,5-dichlorobenzenesulfonyl)piperazin-1-yl]-4-(1H-indol-3-yl)butan-1-one
3-(1H-indol-3-yl)-1-[4-(phenoxyacetyl)piperazin-1-yl]propan-1-one

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