2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-methylaniline,dihydrochloride

Names

[ CAS No. ]:
411208-45-2

[ Name ]:
2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-methylaniline,dihydrochloride

[Synonym ]:
dihydrochloride
2-(2'-Amino-4'-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride
2-(2 inverted exclamation marka-Amino-4 inverted exclamation marka-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride
N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine
MADAM dihydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
426.4ºC at 760 mmHg

[ Molecular Formula ]:
C16H22Cl2N2S

[ Molecular Weight ]:
345.33000

[ Flash Point ]:
211.7ºC

[ Exact Mass ]:
344.08800

[ PSA ]:
54.56000

[ LogP ]:
5.97520

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2930909090

Synthetic Route

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Precursor & DownStream

Precursor

  • N,N-dimethyl-2-(4-methyl-2-nitrophenyl)sulfanylbenzamide
  • 4-Bromo-3-nitrotoluene
  • N,N-dimethyl-2-sulfanylbenzamide
  • Thiosalicylic acid
  • 2-(4'-methyl-2'-nitrophenylthio)benzoic acid

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.

J. Med. Chem. 45 , 1253-1258, (2002)

A series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepineph...

Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.

J. Pharmacol. Exp. Ther. 304 , 81-87, (2003)

Serotonin transporter has a key-role in regulation of serotoninergic function, and is involved in numerous neurodegenerative and psychiatric disorders. To obtain an efficient radioactive ligand allowi...


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