2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-methylaniline,dihydrochloride

Names

[ CAS No. ]:
411208-45-2

[ Name ]:
2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-methylaniline,dihydrochloride

[Synonym ]:
dihydrochloride
2-(2'-Amino-4'-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride
2-(2 inverted exclamation marka-Amino-4 inverted exclamation marka-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride
N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine
MADAM dihydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
426.4ºC at 760 mmHg

[ Molecular Formula ]:
C16H22Cl2N2S

[ Molecular Weight ]:
345.33000

[ Flash Point ]:
211.7ºC

[ Exact Mass ]:
344.08800

[ PSA ]:
54.56000

[ LogP ]:
5.97520

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N,N-dimethyl-2-(4-methyl-2-nitrophenyl)sulfanylbenzamide
  • 4-Bromo-3-nitrotoluene
  • N,N-dimethyl-2-sulfanylbenzamide
  • Thiosalicylic acid
  • 2-(4'-methyl-2'-nitrophenylthio)benzoic acid

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.

J. Med. Chem. 45 , 1253-1258, (2002)

A series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepineph...

Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.

J. Pharmacol. Exp. Ther. 304 , 81-87, (2003)

Serotonin transporter has a key-role in regulation of serotoninergic function, and is involved in numerous neurodegenerative and psychiatric disorders. To obtain an efficient radioactive ligand allowi...


More Articles

Related Compounds

  • 1-Methyl-4,5-dihydro-1H-imidazol-2-amine hydrochloride
  • 7-(oxiran-2-yl)-3,4-dihydro-2H-1,5-benzodioxepine
  • 2-(1H-1,3-benzodiazol-2-yl)-1-(furan-2-yl)ethan-1-one hydrochloride
  • 5-amino-3-(diethylamino)-1H-pyrazole-4-carbonitrile
  • 3,6,7,8-tetrahydro-2H-spiro[[1,4]dioxino[2,3-g]isoquinoline-9,1'-cyclopentane] hydrochloride
  • 2,3,4,6-Tetra-O-acetyl-beta-D-galactopyranosyl peg3-azide
  • CID 11439805
  • 2-Methoxy-1-(5-methylfuran-2-yl)ethan-1-amine
  • 2-{[4-amino-5-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N-(1-cyanocyclohexyl)acetamide
  • (3aR,4S,9bS)-6-ethoxy-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid
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