2,6-Dichloropyrazine

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Names

[ Name ]:
2,6-Dichloropyrazine

[Synonym ]:
3,5-dichloropyrazine
2,6-dichloropyridazine
Pyrazine,2,6-dichloro
1,6-dichloroypyrazine
Pyrazine, 2,6-dichloro-
2,5-DICHLORO-P-XYLENE
2,6-dichloro-pyrazine
M-Dichloropyrazine
2,6-CHLORO PYRAZINE
2,6-dichloro-pyrazin
2,6-Dichloropyrazine
6-Dichloropyrazine
2,6-Dichlor-pyrazin
EINECS 225-316-8
MFCD00006125

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
187.5±35.0 °C at 760 mmHg

[ Melting Point ]:
55-58 °C(lit.)

[ Molecular Formula ]:
C₄H₂Cl₂N₂

[ Molecular Weight ]:
148.97

[ Flash Point ]:
83.8±11.5 °C

[ Exact Mass ]:
147.959503

[ PSA ]:
25.78000

[ LogP ]:
1.57

[ Vapour Pressure ]:
0.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.559

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R20/21/22;R36/37/38

[ Safety Phrases ]:
S26-S37/39-S36/37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Pyrazine 1,4-Dioxide
Pyrazine
2-Chloropyrazine
Pyrazine, 2-chloro-,4-oxide
Chlorine
Pyrazine, 2-chloro-,1-oxide
Water

DownStream

2,6-Dimethoxypyrazine
2-Chloro-6-methoxypyrazine
6-Chloro-2-pyrazinecarboxamide
3,5-Dichloro-2-pyrazinecarboxylic acid
2-Chloro-6-methylpyrazine
6-chlorpyrazin-2-amin
2,6-Diiodopyrazine
2-Chloro-6-phenylpyrazine
tert-butyl 4-(6-chloropyrazin-2-yl)piperazine-1-carboxylate
6-Chloro-N-cyclopropylpyrazin-2-amine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Syntheses and properties of two-dimensional, dicationic nonlinear optical chromophores based on pyrazinyl cores.

J. Org. Chem. 75(24) , 8550-63, (2010)

Six new dicationic 2D nonlinear optical (NLO) chromophores with pyrazinyl-pyridinium electron acceptors have been synthesized by nucleophilic substitutions of 2,6-dichloropyrazine with pyridyl derivat...

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.

Bioorg. Med. Chem. 21(21) , 6732-41, (2013)

Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.) ...

Synthesis of oxacalixarenes incorporating nitrogen heterocycles: evidence for thermodynamic control.

Org. Lett. 8 , 2755, (2006)

[structure: see text] Oxacalix[2]arene[2]hetarenes are formed in a single step by cyclooligomerization of meta-diphenols with meta-dichlorinated azaheterocycles. The high selectivity for cyclic tetram...

2,6-Dichloropyrazine 1-oxide
2,6-dichloropyrazine carboxaldehyde
2,5-dibutyl-3,6-dichloropyrazine
2,6-dimethyloctacosane
2,6-bis[(dimethylamino)methyl]-1-oxido-4-phenylpyrimidin-1-ium-5-ol
2,6-Dichloro-N-(4-fluorobenzyl)aniline
4-(Cyclopropyloxy)-3-(2-methyl-3-pyridinyl)benzoic acid
2-Fluoro-3-(4-morpholinyl)benzoic acid
3-Cyclopropyl-8-methoxy-6-quinolinecarboxylic acid
3-Methyl-5-oxopyrrolidine-3-carbonitrile
N-(4-methoxyquinolin-8-yl)-1-(prop-2-enoyl)piperidine-4-carboxamide
N-[(3-fluorocyclobutyl)methyl]-4-phenyl-1-(prop-2-enoyl)piperidine-4-carboxamide
Thalidomide-O-PEG3-alcohol
N-[(6-methoxynaphthalen-2-yl)methyl]-N-methyl-1-(prop-2-enoyl)piperidine-4-carboxamide
N-(2-{3-[(1-benzothiophen-3-yl)methyl]piperidin-1-yl}-2-oxoethyl)-N-ethylprop-2-enamide
N-(8-chloro-3,4-dihydro-2H-1-benzopyran-4-yl)-4-(prop-2-enamido)benzamide

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