Acacetin

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Names

[ CAS No. ]:
480-44-4

[ Name ]:
Acacetin

[Synonym ]:
Linarigenin
5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Acacetin
5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one
5,7-Dihydroxy-4'-methoxyflavone
Apigenin-4'-methyl Ether
4'-O-Methylapigenin
Buddleoflavonol
MFCD00016936
4'-Methoxyapigenin
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-
Apigenin 4'-methyl ether
EINECS 207-552-3

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
518.6±50.0 °C at 760 mmHg

[ Melting Point ]:
260-265 °C(lit.)

[ Molecular Formula ]:
C16H12O5

[ Molecular Weight ]:
284.263

[ Flash Point ]:
198.3±23.6 °C

[ Exact Mass ]:
284.068481

[ PSA ]:
79.90000

[ LogP ]:
3.15

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.669

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ3002000
CHEMICAL NAME :
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-
CAS REGISTRY NUMBER :
480-44-4
BEILSTEIN REFERENCE NO. :
0277879
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C16-H12-O5
MOLECULAR WEIGHT :
284.28
WISWESSER LINE NOTATION :
T66 BO EVJ CR DO1& GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
933 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
933 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
50 mg/kg
SEX/DURATION :
female 1 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DJ3002000

[ HS Code ]:
2914509090

Precursor & DownStream

Precursor

  • 2',4',6'-Trihydroxyacetophenone Monohydrate
  • p-Anisoyl chloride
  • 7-(benzyloxy)-5-hydroxy-2-(4-methoxy-3-((1-phenyl-1H-tetrazol-5-yl)oxy)phenyl)-4H-chromen-4-one
  • Trimethylapigenin
  • Linarin
  • 2-(4-methoxyphenyl)-4-oxo-4H-chromene-5,7-diyl bis(4-methoxybenzoate)
  • 5-hydroxy-2-(4-methoxy-3-((1-phenyl-1H-tetrazol-5-yl)oxy)phenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
  • Diosmetin
  • Diosmin

DownStream

  • Phloroglucinol
  • p-Anisic acid
  • 7,4'-Di-O-methylapigenin
  • Isosakuranetin
  • Linarin
  • 4-Hydroxybenzoic acid
  • Scutellarein
  • Apigenin
  • 6-Demethoxytangeretin
  • 5,6,7-trihydroxy-2-(4-methoxyphenyl)chromen-4-one

Customs

[ HS Code ]: 2914509090

[ Summary ]:
HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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Related Compounds

  • acacetin-7-glucoside
  • 3-p-Anisoyl-acacetin
  • Acacetin 7-rutinoside
  • Acacetin 7-O-glucoside
  • acacetin-7-O-rutinoside
  • 6-C-Neohesperidosyl-acacetin
  • 5-(1H-pyrrol-2-yl)pyridine-3-carboxylic acid
  • 6-Chloro-4-(2,3-dihydro-1H-inden-5-yl)-1-methylpyridin-2(1H)-one
  • 4-(4-Tert-butylphenyl)pyrrolidin-3-amine
  • 3-Bromo-5-fluoro-2-methoxy-4-methylpyridine
  • DE(ethoxycarbonyl)torcetrapib
  • 2,6-Dichloro-4-(2,4-difluorophenyl)pyridine
  • Torcetrapib metabolite M13
  • 4H,6H,7H-pyrano[3,4-d][1,2]oxazole-3-carbaldehyde
  • 6-Chloro-2-(6-chloro-5-fluoro-3-pyridinyl)-1H-benzimidazole
  • 1-o-Tolyloxy-cyclopropanecarboxylic acid methyl ester
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