Acacetin

Modify Date: 2024-01-02 17:39:27

Acacetin structure	Common Name	Acacetin
	CAS Number	480-44-4	Molecular Weight	284.263
	Density	1.4±0.1 g/cm3	Boiling Point	518.6±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₂O₅	Melting Point	260-265 °C(lit.)
	MSDS	Chinese USA	Flash Point	198.3±23.6 °C
	Symbol	GHS07	Signal Word	Warning

Use of Acacetin

1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration

Name	5,7-dihydroxy-4'-methoxyflavone
Synonym	More Synonyms

Description	1) Natural acacetin was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.[1]2) Acacetin significantly suppressed the photoreceptor collapse. [1]3) Acacetin significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. [1]4) Acacetin inhibited the generation of the APP-CTF by affecting APP cleavage. [1]5) Acacetin prolongs lifespan of significantly in the dose dependent manner. Acacetin(25 uM) had the greatest effect on longevity, extending mean lifespan significantly by 27.31% at 25 uM concentration
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Natural Products >> Flavonoids Research Areas >> Others
References	[1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127. [2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74.

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Natural Products >> Flavonoids

Research Areas >> Others

References

[1]. Wang X. Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophilamodels of Alzheimer's disease. Sci Rep, 2015 Nov 4, 5:16127.

[2]. Asthana J et al. Acacetin promotes healthy aging by altering stress response in Caenorhabditis elegans. Free Radic Res, 2016 Aug, 50(8):861-74.

Density	1.4±0.1 g/cm3
Boiling Point	518.6±50.0 °C at 760 mmHg
Melting Point	260-265 °C(lit.)
Molecular Formula	C₁₆H₁₂O₅
Molecular Weight	284.263
Flash Point	198.3±23.6 °C
Exact Mass	284.068481
PSA	79.90000
LogP	3.15
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.669
Storage condition	2-8°C

Acacetin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ3002000

CHEMICAL NAME :: 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-

CAS REGISTRY NUMBER :: 480-44-4

BEILSTEIN REFERENCE NO. :: 0277879

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C16-H12-O5

MOLECULAR WEIGHT :: 284.28

WISWESSER LINE NOTATION :: T66 BO EVJ CR DO1& GQ IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 933 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 933 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 50 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	DJ3002000
HS Code	2914509090

Precursor 9
CAS#:480-66-0 2',4',6'-Trihyd... CAS#:100-07-2 p-Anisoyl chloride CAS#:771481-08-4 7-(benzyloxy)-5... CAS#:5631-70-9 Trimethylapigenin
CAS#:480-36-4 Linarin CAS#:110865-07-1 2-(4-methoxyphe... CAS#:771480-96-7 5-hydroxy-2-(4-... CAS#:520-34-3 Diosmetin
CAS#:520-27-4 Diosmin
DownStream 10
CAS#:108-73-6 Phloroglucinol CAS#:100-09-4 p-Anisic acid CAS#:5128-44-9 7,4'-Di-O-methy... CAS#:480-43-3 Isosakuranetin
CAS#:480-36-4 Linarin CAS#:99-96-7 4-Hydroxybenzoi... CAS#:529-53-3 Scutellarein CAS#:520-36-5 Apigenin
CAS#:6601-66-7 6-Demethoxytang... CAS#:6563-66-2 5,6,7-trihydrox...

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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Linarigenin

5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

5,7-Dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Acacetin

5,7-dihydroxy-2-(4-methoxyphenyl)chromen-4-one

5,7-Dihydroxy-4'-methoxyflavone

Apigenin-4'-methyl Ether

4'-O-Methylapigenin

Buddleoflavonol

MFCD00016936

4'-Methoxyapigenin

4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-methoxyphenyl)-

Apigenin 4'-methyl ether

EINECS 207-552-3

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China
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China
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China
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Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
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Acacetin

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