Acacetin
Acacetin structure
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Common Name | Acacetin | ||
|---|---|---|---|---|
| CAS Number | 480-44-4 | Molecular Weight | 284.263 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 518.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H12O5 | Melting Point | 260-265 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 198.3±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa.
PLoS ONE 10 , e0127060, (2015) Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified ... |
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Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood.
Inflammation 38(2) , 858-70, (2015) Cyclooxygenase 2 (COX-2) and the production of cytokines/chemokines are important targets for the modulation of the inflammatory response. Although a large variety of inhibitors of these pathways have been commercialized, some of those inhibitors present seve... |
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Simultaneous quantification of 25 active constituents in the total flavonoids extract from Herba Desmodii Styracifolii by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
J. Sep. Sci. 38(7) , 1156-63, (2015) A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and fo... |
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The seed of the Amazonian fruit Couepia bracteosa exhibits higher scavenging capacity against ROS and RNS than its shell and pulp extracts.
Food Funct. 6 , 3081-90, (2015) Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, which may be used for protecting human health against oxidat... |
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Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.
Sci. Rep. 5 , 16127, (2015) The human β-amyloid (Aβ) cleaving enzyme (BACE-1) is a target for Alzheimer's disease (AD) treatments. This study was conducted to determine if acacetin extracted from the whole Agastache rugosa plant had anti-BACE-1 and behavioral activities in Drosophila me... |
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Cytotoxic fraction from Artemisia sacrorum Ledeb. against three human cancer cell lines and separation and identification of its compounds.
Nat. Prod. Res. 26(16) , 1483-91, (2012) Artemisia sacrorum Ledeb. was extracted by 95% ethanol and water, respectively. By partitioning the 95% ethanol extract successively with different solvents and separating the water extract by macroporous resin, nine separate parts were obtained. According to... |
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Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages.
Int. J. Mol. Sci. 15(7) , 11510-22, (2014) Expression level of Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) receptors is one of the most important factors of TRAIL-mediated apoptosis in cancer cells. We here report for the first time data concerning TRAIL-R1 and TRAIL-R2 receptor ex... |
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Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.
Bioorg. Med. Chem. 19 , 2842-9, (2011) CYP1A1 and CYP1B1 are two extrahepatic enzymes that have been implicated in carcinogenesis and cancer progression. Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class of flavonoids, is a widely accepted paradigm that supports ... |
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[The influence of different processing on the content of flavones of Dendranthema morifolium].
Zhong Yao Cai 35(5) , 702-4, (2012) To investigate the effect of different processing methods on the content of luteolin-7-O-beta-D-glucoside, acacetin-7-O-beta-D-glucoside, luteolin, and acacetin of Dendranthema morifolium.The optimal conditions were achieved on phenomenex, synergi Fusion-RP (... |
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Acacetin blocks kv1.3 channels and inhibits human T cell activation.
Cell Physiol. Biochem. 34(4) , 1359-72, (2014) Acacetin, a natural flavonoid compound, has been proven to exert anti-inflammatory and immunomodulatory effects. Kv1.3 channels, highly expressed in human T cells, are attractive therapeutic targets to treat inflammatory and immunological disorders. The prese... |