2,4-Dichloro-6-methylpyrimidine

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Names

[ CAS No. ]:
5424-21-5

[ Name ]:
2,4-Dichloro-6-methylpyrimidine

[Synonym ]:
2,4-dichloro-6-methyl pyrimidine
2,4,5-TRIFLUOROBENZAMIDINE HYDROCHLORIDE
2,4-dichloro-6-methyl-pyrimidine
EINECS 226-563-4
2,4-Dichloro-6-methylpyrimidine
Pyrimidine,2,4-dichloro-6-methyl
MFCD00006064
Pyrimidine, 2,4-dichloro-6-methyl-
2,6-dichloro-4-methylpyrimidine
6-methyl-2,4-dichloropyrimidine
2,4-Dichlor-6-methyl-pyrimidin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
219.0±20.0 °C at 760 mmHg

[ Melting Point ]:
44-47 °C(lit.)

[ Molecular Formula ]:
C5H4Cl2N2

[ Molecular Weight ]:
163.005

[ Flash Point ]:
107.0±7.4 °C

[ Exact Mass ]:
161.975159

[ PSA ]:
25.78000

[ LogP ]:
1.62

[ Vapour Pressure ]:
0.2±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.551

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S27-S36/37/39-S45

[ RIDADR ]:
UN 3263 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6-Methyluracil
  • 5-Bromo-2,4-dichloro-6-methylpyrimidine
  • 5-Bromo-6-methylpyrimidine-2,4-diol
  • 6-Methyl-2-(methylthio)-1H-pyrimidin-4-one
  • 5-bromo-6-methyl-2-methylsulfanyl-1H-pyrimidin-4-one
  • Tributylamine suppliers in China
  • Triethylamine
  • N,N-Dimethylaniline
  • phosphoryl trichloride

DownStream

  • 4-Hydroxy-6-methylpyrimidine
  • 2-Chloro-4-ethoxy-6-methylpyrimidine
  • 4-(2-chloro-6-methylpyrimidin-4-yl)morpholine
  • 4-(4-CHLORO-6-METHYL-2-PYRIMIDINYL)MORPHOLINE
  • 2-Amino-6-hydroxy-4-methylpyrimidine
  • 4-Chloro-6-methyl-2-pyrimidinamine
  • 2-chloro-4-methyl-6-piperidinopyrimidine
  • 4-chloro-2-methyl-6-piperidin-1-ylpyrimidine
  • α,α'-benzenedimethanol-d4
  • 4-Chloro-2-methyl-6-pyrrolidin-1-yl-pyrimidine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

4-Arylvinyl-2,6-di(pyridin-2-yl)pyrimidines: synthesis and optical properties.

J. Org. Chem. 76(10) , 3837-45, (2011)

A series of 4-arylvinyl-2,6-di(pyridin-2-yl)pyrimidines have been efficiently prepared by a double cross-coupling reaction between 2,4-dichloro-6-methylpyrimidine and 2-(tributylstannyl)pyridine, foll...

Fluorous synthesis of disubstituted pyrimidines.

Org. Lett. 5(7) , 1011-3, (2003)

[reaction: see text] The fluorous synthesis of disubstituted pyrimidines is carried out by attaching 2,4-dichloro-6-methylpyrimidine with 1H,1H,2H,2H-perfluorodecanethiol. The tagged substrate is subs...

Novel inhibitors of Rac1 in metastatic breast cancer.

P. R. Health Sci. J. 29(4) , 348-56, (2010)

Rho family GTPases are molecular switches that control signaling pathways regulating a myriad of cellular functions. Rac1, a Rho family member, plays a critical role in several aspects of tumorigenesi...


More Articles

Related Compounds

  • 5-Bromo-2,4-dichloro-6-methylpyrimidine
  • 2,4-Dichloro-6-methylpyrimidine-5-carbonitrile
  • 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde
  • 5-chloromethyl-2,4-dichloro-6-methylpyrimidine
  • Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate
  • 2,4-dichloro-6-(chloromethyl)-5-methylpyrimidine
  • 6-Ethoxypyridine-3-carboxamide
  • (4-ethylphenyl)[7-fluoro-4-(3-methylphenyl)-1,1-dioxido-4H-1,4-benzothiazin-2-yl]methanone
  • [4-(3,4-dimethylphenyl)-7-fluoro-1,1-dioxido-4H-1,4-benzothiazin-2-yl](4-ethylphenyl)methanone
  • [4-(3,5-dimethylphenyl)-7-fluoro-1,1-dioxido-4H-1,4-benzothiazin-2-yl](4-ethylphenyl)methanone
  • (4-ethylphenyl)[4-(3-ethylphenyl)-7-fluoro-1,1-dioxido-4H-1,4-benzothiazin-2-yl]methanone
  • (4-ethylphenyl)[7-fluoro-4-(3-methoxyphenyl)-1,1-dioxido-4H-1,4-benzothiazin-2-yl]methanone
  • [4-(4-ethoxyphenyl)-7-fluoro-1,1-dioxido-4H-1,4-benzothiazin-2-yl](4-ethylphenyl)methanone
  • [4-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1,1-dioxido-4H-1,4-benzothiazin-2-yl](4-ethylphenyl)methanone
  • (4-ethylphenyl)[7-fluoro-4-(4-fluorophenyl)-1,1-dioxido-4H-1,4-benzothiazin-2-yl]methanone
  • [4-(3-chlorophenyl)-7-fluoro-1,1-dioxido-4H-1,4-benzothiazin-2-yl](4-ethylphenyl)methanone
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