Siastatin B microbial

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Names

[ CAS No. ]:
54795-58-3

[ Name ]:
Siastatin B microbial

[Synonym ]:
(3S,4S,5R,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.48g/cm3

[ Boiling Point ]:
579.2ºC at 760 mmHg

[ Molecular Formula ]:
C8H14N2O5

[ Molecular Weight ]:
218.20700

[ Flash Point ]:
304.1ºC

[ Exact Mass ]:
218.09000

[ PSA ]:
118.89000

[ Index of Refraction ]:
1.581

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM6125400
CHEMICAL NAME :
3-Piperidinecarboxylic acid, 6-(acetylamino)-4,5-dihydroxy-, (3S-(3-alpha,4-alpha,5-alpha,6- beta))-
CAS REGISTRY NUMBER :
54795-58-3
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C8-H14-N2-O5
MOLECULAR WEIGHT :
218.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,963,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
TM6125400

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Contributions of NanI sialidase to Caco-2 cell adherence by Clostridium perfringens type A and C strains causing human intestinal disease.

Infect. Immun. 82(11) , 4620-30, (2014)

Previous studies showed that Clostridium perfringens type D animal disease strain CN3718 uses NanI sialidase for adhering to enterocyte-like Caco-2 cells. The current study analyzed whether NanI is si...

Syntheses and activities of N-substituted derivatives of siastatin B.

J. Antibiot. 45(10) , 1662-8, (1992)

N-Substituted derivatives of siastatin B have been obtained by a chemical modification. Some derivatives showed potent inhibitory activities against Streptococcus sp. and Clostridium perfringens neura...

Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.

J. Antibiot. 46(12) , 1883-9, (1993)

Two epimers of siastatin B, 3-episiastatin B (3) and 3,4-diepisiastatin B (4), were obtained by the chemical modification of siastatin B. Compound 3 showed marked inhibitory activity against influenza...


More Articles

Related Compounds

  • 3-Pyridinecarboxylicacid,6-(acetylamino)-1,2,5,6-tetrahydro-5-hydroxy-,(5S-trans)-(9CI)
  • EBELACTONE B
  • Carda-4,20(22)-dienolide,14-hydroxy-19-oxo-3-(b-D-xylopyranosyloxy)-, (3b)- (9CI)
  • Arphamenine B hemisulfate
  • 2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, monohydrochloride,(3R,4R)- (9CI)
  • Coralloidin B