4 hydroxy tolbutamide

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Names

[ CAS No. ]:
5719-85-7

[ Name ]:
4 hydroxy tolbutamide

[Synonym ]:
1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea
Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)-
hydroxymethyl-TB
4-OH-tolbutamide
Methylhydroxytolbutamide
hydroxymethyltolbutamide
Hydroxytolbutamide
4-Hydroxytolbutamide
4 hydroxy tolbutamide
N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide
[14C]-Hydroxytolbutamide
N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide
1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
100-102ºC

[ Molecular Formula ]:
C12H18N2O4S

[ Molecular Weight ]:
286.347

[ Flash Point ]:
2℃

[ Exact Mass ]:
286.098724

[ PSA ]:
103.88000

[ LogP ]:
0.70

[ Index of Refraction ]:
1.553

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 12 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F,Xn

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
16-36/37-24/25

[ RIDADR ]:
UN 1648 3 / PGII

[ WGK Germany ]:
3

[ HS Code ]:
29350090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Carboxytolbutamide Methyl Ester
  • Tolbutamide
  • Benzoic acid,4-(aminosulfonyl)-, methyl ester
  • 1-Isocyanatobutane

DownStream

  • 1-butyl-3-(4-formylphenyl)sulfonylurea

Articles

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

J. Pharm. Pharmacol. 66(9) , 1339-46, (2014)

The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates 7-methoxy-4-...

Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.

Food Chem. Toxicol. 76 , 94-102, (2015)

meso-Dihydroguaiaretic acid (MDGA) is a major component of Myristica fragrans and Machilus thunbergii that is traditionally used as a spice and for medicinal purposes. Despite reports of various biolo...

Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Food Chem. Toxicol. 68 , 117-27, (2014)

• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...


More Articles

Related Compounds

  • (4-hydroxy-3,5-diiodophenyl)-(1H-indol-3-yl)methanone
  • 4-hydroxy-7-nitroimidazo[4,5-b]pyridine
  • 4-Hydroxy-3,5-diiodophenylacetic acid
  • 4-hydroxy-4-oxobutanoate,[2-methyl-2-(4-piperidin-1-ylphenyl)propyl]azanium
  • 4-Hydroxy-3-[[2-oxo-1-(phenylcarbamoyl)propyl]azo]benzenesulfonamide
  • 4-hydroxy-3,4-diphenyl-oxolan-2-one
  • sodium 1-(propan-2-yl)-1H-pyrazole-4-sulfinate
  • 3-(1-methyl-1H-pyrrol-2-yl)prop-2-ynoic acid
  • 5-bromo-1H-indazole-3-sulfonyl fluoride
  • {5-Azaspiro[3.4]octan-7-yl}methanamine
  • Ethyl 2-(2-aminopropoxy)acetate
  • rac-(3R,4R)-4-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)pyrrolidin-3-ol
  • 3-{6-Oxabicyclo[3.2.1]octan-2-yl}propan-1-ol
  • 4-amino-5-(3-tert-butyl-1-methyl-1H-pyrazol-4-yl)-1-methylpyrrolidin-2-one
  • Ethyl 3-(azetidin-2-yl)prop-2-ynoate
  • 1-[1-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]ethan-1-amine
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