4 hydroxy tolbutamide

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Names

[ CAS No. ]:
5719-85-7

[ Name ]:
4 hydroxy tolbutamide

[Synonym ]:
1-Butyl-3-(4-hydroxymethylphenyl)sulfonylurea
Benzenesulfonamide, N-[(butylamino)carbonyl]-4-(hydroxymethyl)-
hydroxymethyl-TB
4-OH-tolbutamide
Methylhydroxytolbutamide
hydroxymethyltolbutamide
Hydroxytolbutamide
4-Hydroxytolbutamide
4 hydroxy tolbutamide
N-(Butylcarbamoyl)-4-(hydroxymethyl)benzenesulfonamide
[14C]-Hydroxytolbutamide
N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide
1-butyl-3-[4-(hydroxymethyl)phenyl]sulfonylurea

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Melting Point ]:
100-102ºC

[ Molecular Formula ]:
C12H18N2O4S

[ Molecular Weight ]:
286.347

[ Flash Point ]:
2℃

[ Exact Mass ]:
286.098724

[ PSA ]:
103.88000

[ LogP ]:
0.70

[ Index of Refraction ]:
1.553

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 12 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H312 + H332-H319

[ Precautionary Statements ]:
P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F,Xn

[ Risk Phrases ]:
11-20/21/22-36

[ Safety Phrases ]:
16-36/37-24/25

[ RIDADR ]:
UN 1648 3 / PGII

[ WGK Germany ]:
3

[ HS Code ]:
29350090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Carboxytolbutamide Methyl Ester
  • Tolbutamide
  • Benzoic acid,4-(aminosulfonyl)-, methyl ester
  • 1-Isocyanatobutane

DownStream

  • 1-butyl-3-(4-formylphenyl)sulfonylurea

Articles

The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.

J. Pharm. Pharmacol. 66(9) , 1339-46, (2014)

The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates 7-methoxy-4-...

Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.

Food Chem. Toxicol. 76 , 94-102, (2015)

meso-Dihydroguaiaretic acid (MDGA) is a major component of Myristica fragrans and Machilus thunbergii that is traditionally used as a spice and for medicinal purposes. Despite reports of various biolo...

Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Food Chem. Toxicol. 68 , 117-27, (2014)

• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...


More Articles

Related Compounds

  • (4-hydroxy-3,5-diiodophenyl)-(1H-indol-3-yl)methanone
  • 4-hydroxy-7-nitroimidazo[4,5-b]pyridine
  • 4-Hydroxy-3,5-diiodophenylacetic acid
  • 4-hydroxy-4-oxobutanoate,[2-methyl-2-(4-piperidin-1-ylphenyl)propyl]azanium
  • 4-Hydroxy-3-[[2-oxo-1-(phenylcarbamoyl)propyl]azo]benzenesulfonamide
  • 4-hydroxy-3,4-diphenyl-oxolan-2-one
  • D-Ribitol, 2,3,4-tris-O-(phenylmethyl)-5-O-2-propenyl-1-O-(2,3,5-tri-O-benzoyl-I(2)-D-ribofuranosyl)-
  • Phenylmethyl hexahydro-2-phenyl-7,8-bis(phenylmethoxy)-5H-1,3-dioxino[5,4-b]pyridine-5-carboxylate
  • 5,13a-Etheno-1H,13aH-cyclopenta[5,6]naphtho[2,1-c][1,2,4]triazolo[1,2-a][1,2]diazine-1,3(2H)-dione
  • D-Alanine, N-[N-[(phenylmethoxy)carbonyl]-L-I+/--aspartyl]-, 1-(1-methylethyl) 4-(phenylmethyl) ester
  • Cytidine 5a(2)-(trihydrogen diphosphate), 2a(2)-deoxy-, Pa(2)-[2-(trimethylammonio)ethyl] ester, inner salt
  • Nonacosane, 1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13-heptacosafluoro-15-iodo-
  • 2-Propanesulfinamide, N-[(1R)-1-[4-(5-cyano-2-methoxy-3-pyridinyl)phenyl]ethyl]-2-methyl-, [S(R)]-
  • Adenosine 5a(2)-(trihydrogen diphosphate), Pa(2)a5a(2)-ester with 1-I(2)-D-ribofuranosylpyridinium, inner salt
  • L-Proline, 1,1a(2)-[dithiobis(2-methyl-1-oxo-3,1-propanediyl)]bis-, bis[(4-nitrophenyl)methyl] ester
  • L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl-L-phenylalanyl-, didodecyl ester
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