4 hydroxy tolbutamide
4 hydroxy tolbutamide structure
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Common Name | 4 hydroxy tolbutamide | ||
|---|---|---|---|---|
| CAS Number | 5719-85-7 | Molecular Weight | 286.347 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C12H18N2O4S | Melting Point | 100-102ºC | |
| MSDS | Chinese USA | Flash Point | 2℃ | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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The in-vitro effect of complementary and alternative medicines on cytochrome P450 2C9 activity.
J. Pharm. Pharmacol. 66(9) , 1339-46, (2014) The aim of this study is to establish the inhibitory effects of 14 commonly used complementary and alternative medicines (CAM) on the metabolism of cytochrome P450 2C9 (CYP2C9) substrates 7-methoxy-4-trifluoromethyl coumarine (MFC) and tolbutamide. CYP2C9 is ... |
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Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice.
Food Chem. Toxicol. 76 , 94-102, (2015) meso-Dihydroguaiaretic acid (MDGA) is a major component of Myristica fragrans and Machilus thunbergii that is traditionally used as a spice and for medicinal purposes. Despite reports of various biological activities exerted by MDGA, there is no information r... |
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Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition
Food Chem. Toxicol. 68 , 117-27, (2014) • BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacokinetics of drugs metabolized by CYPs/UGTs. |
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Metabolic drug-drug interaction potential of macrolactin A and 7-O-succinyl macrolactin A assessed by evaluating cytochrome P450 inhibition and induction and UDP-glucuronosyltransferase inhibition in vitro.
Antimicrob. Agents Chemother. 58(9) , 5036-46, (2014) Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureu... |
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Inhibitory mechanisms of celastrol on human liver cytochrome P450 1A2, 2C19, 2D6, 2E1 and 3A4.
Xenobiotica 45 , 571-7, (2015) 1. The present study was conducted to examine the possibility of herb-drug interaction by celastrol, which is a main compound isolated from Tripterygium wilfordii Hook F. using human liver microsomes with cocktail methods. Focused on its inhibitory manner on ... |
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Effects of Guanxinning injection on rat cytochrome P450 isoforms activities in vivo and in vitro.
Xenobiotica 45 , 481-7, (2015) 1. We aimed to investigate the regulatory effects of Guanxinning injection (GXNI) on activities of cytochrome P1A2 (CYP1A2), CYP2C11, CYP2D1 and CYP3A1/2 by probe drugs in rats in vivo and in vitro. 2. GXNI-treated and blank control groups were administered G... |
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Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients.
Mol. Cancer Ther. 14 , 2874-86, (2015) This study aims to systematically determine the activities and expressions of cytochrome P450s (CYP) in hepatocellular carcinoma (HCC) patients to support their optimal use in personalized treatment of HCC. Activities of seven major drug-metabolizing CYP enzy... |
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Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies.
Xenobiotica 44(7) , 615-26, (2014) 1. Cytochrome P450 enzyme system is the most important contributor to oxidative metabolism of drugs. Modification, and more specifically inhibition, of this system is an important determinant of several drug-drug interactions (DDIs). 2. Effects of the antimal... |
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Influences of Re Du Ning Injection, a traditional Chinese medicine injection, on the CYP450 activities in rats using a cocktail method.
J. Ethnopharmacol. 174 , 426-36, (2015) Re Du Ning Injection (RDN), a traditional Chinese medicine injection, is made from the extracts of Lonicerae japonicae flos (LJF), Artemisiae annuae herba (AAH) and Gardeniae fructus (GF). Since last decade, RDN has been widely used in China for the treatment... |
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Cytochrome P450 2C9 phenotyping using low-dose tolbutamide.
Eur. J. Clin. Pharmacol. 60(3) , 165-71, (2004) The hypoglycaemic drug tolbutamide is used for assessment of CYP2C9 activity in vivo. However, therapeutically active doses of 500 mg bear the risk of hypoglycaemia, and a tolbutamide-derived parameter based on a single plasma or urine concentration reflectin... |