SU4312

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Names

[ CAS No. ]:
5812-07-7

[ Name ]:
SU4312

[Synonym ]:
3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
NSC 86429

Chemical & Physical Properties

[ Density]:
1.219g/cm3

[ Boiling Point ]:
497.1ºC at 760 mmHg

[ Molecular Formula ]:
C17H16N2O

[ Molecular Weight ]:
264.32200

[ Flash Point ]:
254.5ºC

[ Exact Mass ]:
264.12600

[ PSA ]:
32.34000

[ LogP ]:
3.38330

[ Index of Refraction ]:
1.683

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Articles

The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.

Br. J. Pharmacol. 168(5) , 1201-14, (2013)

SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative dis...

Automated image-based phenotypic analysis in zebrafish embryos.

Dev. Dyn. 238(3) , 656-63, (2009)

Presently, the zebrafish is the only vertebrate model compatible with contemporary paradigms of drug discovery. Zebrafish embryos are amenable to automation necessary for high-throughput chemical scre...


More Articles

Related Compounds

  • (Z)-SU4312 (Z)-SU4312 (Z)-SU4312
  • Methyl 4-[[(1,2,3-trimethyl-1H-indol-5-yl)carbonyl]amino]benzoate
  • N-(4-acetamidophenyl)-2-((4-(2-(cyclohexylamino)-2-oxoethyl)thiazol-2-yl)thio)acetamide
  • 2-((4-(2-oxo-2-((4-sulfamoylphenyl)amino)ethyl)thiazol-2-yl)thio)-N-(p-tolyl)acetamide
  • 3-fluoro-N-(2-(6-(methylthio)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)benzamide
  • 4-fluoro-N-(2-(6-(methylthio)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)benzamide
  • 2-(4-fluorophenyl)-N-(2-(6-(methylthio)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)acetamide
  • N-(2-(6-(ethylthio)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-fluorobenzamide
  • N-(2-(6-(ethylthio)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-4-fluorobenzamide
  • N-(2-(6-(ethylthio)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-2-(4-fluorophenyl)acetamide
  • N-(3-fluorophenyl)-2-(2-methyl-4-oxo-7-phenylthiazolo[4,5-d]pyridazin-5(4H)-yl)acetamide
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