3'-bromo-5'-chloro-2'-hydroxyacetophenone

Suppliers

Names

[ CAS No. ]:
59443-15-1

[ Name ]:
3'-bromo-5'-chloro-2'-hydroxyacetophenone

[Synonym ]:
MFCD00857068
1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone

Chemical & Physical Properties

[ Density]:
1.691g/cm3

[ Boiling Point ]:
297.8ºC at 760 mmHg

[ Melting Point ]:
100-103 °C(lit.)

[ Molecular Formula ]:
C8H6BrClO2

[ Molecular Weight ]:
249.48900

[ Flash Point ]:
133.9ºC

[ Exact Mass ]:
247.92400

[ PSA ]:
37.30000

[ LogP ]:
3.01070

[ Index of Refraction ]:
1.604

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2914700090

Synthetic Route

Precursor & DownStream

Precursor

  • 5'-Chloro-2'-hydroxyacetophenone

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Inhibitors and promoters of tubulin polymerization: synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents.

Bioorg. Med. Chem. 19(8) , 2659-65, (2011)

A series of dihalogenated chalcones and structurally related dienones were synthesized and evaluated for their antiproliferative activity in 10 different cancer cell lines and for their effect on micr...

Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.

J. Org. Chem. 74(7) , 2755-9, (2009)

A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner...

Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors.

J. Med. Chem. 55 , 7104-13, (2012)

A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disord...


More Articles


Related Compounds

  • trans-2-bromo-5'-chloro-2'-hydroxystilbene
  • 5'-Chloro-2'-hydroxyacetophenone
  • 3'-Bromo-4'-fluoro-5'-hydroxyacetophenone
  • 3',5'-Dibromo-2'-hydroxyacetophenone
  • 3',5'-Dimethyl-2'-hydroxyacetophenone
  • 3',5'-O-Diacetyl-6-chloro-2'-deoxy-2'-fluoroguanosine