3'-bromo-5'-chloro-2'-hydroxyacetophenone
Suppliers
Names
[ CAS No. ]:
59443-15-1
[ Name ]:
3'-bromo-5'-chloro-2'-hydroxyacetophenone
[Synonym ]:
MFCD00857068
1-(3-bromo-5-chloro-2-hydroxyphenyl)ethanone
Chemical & Physical Properties
[ Density]:
1.691g/cm3
[ Boiling Point ]:
297.8ºC at 760 mmHg
[ Melting Point ]:
100-103 °C(lit.)
[ Molecular Formula ]:
C8H6BrClO2
[ Molecular Weight ]:
249.48900
[ Flash Point ]:
133.9ºC
[ Exact Mass ]:
247.92400
[ PSA ]:
37.30000
[ LogP ]:
3.01070
[ Index of Refraction ]:
1.604
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant;
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ HS Code ]:
2914700090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2914700090
[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%
Articles
Bioorg. Med. Chem. 19(8) , 2659-65, (2011)
A series of dihalogenated chalcones and structurally related dienones were synthesized and evaluated for their antiproliferative activity in 10 different cancer cell lines and for their effect on micr...
J. Org. Chem. 74(7) , 2755-9, (2009)
A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner...
J. Med. Chem. 55 , 7104-13, (2012)
A series of substituted chromone/chroman-4-one derivatives has been synthesized and evaluated as novel inhibitors of SIRT2, an enzyme involved in aging-related diseases, e.g., neurodegenerative disord...