Gamma-glutamylcysteine

Suppliers

Names

[ CAS No. ]:
636-58-8

[ Name ]:
Gamma-glutamylcysteine

[Synonym ]:
Glutathione Impurity D
L-gamma-glutamyl-L-cysteine
(2S)-2-amino-5-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-5-oxopentanoic acid
g-L-Glutamyl-L-cysteine
5-L-Glutamyl-L-cysteine
(S)-2-amino-5-(((R)-1-carboxy-2-mercaptoethyl)amino)-5-oxopentanoic acid
(Des-Gly)-Glutathione (reduced)

Chemical & Physical Properties

[ Density]:
1.436g/cm3

[ Boiling Point ]:
592.4ºC at 760 mmHg

[ Melting Point ]:
167℃

[ Molecular Formula ]:
C₈H₁₄N₂O₅S

[ Molecular Weight ]:
250.27200

[ Flash Point ]:
312.1ºC

[ Exact Mass ]:
250.06200

[ PSA ]:
168.52000

[ Index of Refraction ]:
1.57

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

phthaloyl-l-glutamic anhydride
(R)-3-L-γ-glutamyl-2,2-dimethyl-thiazolidine-4-carboxylic acid
L-cysteine
L-(+)Sodium glutamate
bis-gamma-glutamylcystine
L-alanine
Glutathione
L(-)-Glutathione
N-benzyloxycarbonyl-L-glutamic acid-5-hydrazide

DownStream

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Endogenic oxidative stress response contributes to glutathione over-accumulation in mutant Saccharomyces cerevisiae Y518.

Appl. Microbiol. Biotechnol. 99 , 7069-78, (2015)

Mechanisms of glutathione (GSH) over-accumulation in mutant Saccharomyces cerevisiae Y518 screened by ultraviolet and nitrosoguanidine-induced random mutagenesis were studied. Y518 accumulated higher ...