Gamma-glutamylcysteine

Gamma-glutamylcysteine Structure
Gamma-glutamylcysteine structure
Common Name Gamma-glutamylcysteine
CAS Number 636-58-8 Molecular Weight 250.27200
Density 1.436g/cm3 Boiling Point 592.4ºC at 760 mmHg
Molecular Formula C8H14N2O5S Melting Point 167℃
MSDS Chinese USA Flash Point 312.1ºC
Symbol GHS07
GHS07
Signal Word Warning

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion an...

Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model.

Food Chem. Toxicol. 76 , 109-15, (2015)

In recent years, there has been a growing interest to explore the responsiveness to injury in steatotic hepatocyte. VL-17A cells, which express ADH and Cyp2E1 overloaded with free fatty acids (1 mM of oleic and palmitic acid 2:1) showed an increased oxidative...

Endogenic oxidative stress response contributes to glutathione over-accumulation in mutant Saccharomyces cerevisiae Y518.

Appl. Microbiol. Biotechnol. 99 , 7069-78, (2015)

Mechanisms of glutathione (GSH) over-accumulation in mutant Saccharomyces cerevisiae Y518 screened by ultraviolet and nitrosoguanidine-induced random mutagenesis were studied. Y518 accumulated higher levels of GSH and L-cysteine than its wild-type strain. RNA...

Hepatic metabolism of sulfur amino acids in db/db mice.

Food Chem. Toxicol. 53 , 180-6, (2013)

To determine the effect of type-2 diabetes and obesity on the hepatic metabolism of sulfur amino acids, hepatic sulfur amino acid metabolism was determined in db/db mice. Hepatic methionine was markedly decreased in db/db mice, although the hepatic activity o...

De novo expression of parvalbumin in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair.

Glia 63(4) , 567-94, (2015)

The calcium-binding protein parvalbumin (PV) hallmarks subpopulations of interneurons in the murine brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing ...

Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells.

Toxicol. Lett. 216(2-3) , 159-70, (2013)

"Ecstasy" (3,4-methylenedioxymethamphetamine or MDMA) is a widely abused recreational drug, reported to produce neurotoxic effects, both in laboratory animals and in humans. MDMA metabolites can be major contributors for MDMA neurotoxicity. This work studied ...

Selective extraction of thiol-containing peptides in seawater using Tween 20-capped gold nanoparticles followed by capillary electrophoresis with laser-induced fluorescence.

J. Chromatogr. A. 1220 , 162-8, (2012)

This study combines Tween 20-capped gold nanoparticles (Tween 20-AuNPs) with capillary electrophoresis (CE) for ultrasensitive detection of thiol-containing peptides, including glutathione (GSH), γ-glutamylcysteine (γ-GCS), and phytochelatin analogs. By formi...

Fine tuning of reactive oxygen species homeostasis regulates primed immune responses in Arabidopsis.

Mol. Plant Microbe Interact. 26(11) , 1334-44, (2013)

Selected stimuli can prime the plant immune system for a faster and stronger defense reaction to pathogen attack. Pretreatment of Arabidopsis with the chemical agent β-aminobutyric acid (BABA) augmented H2O2 and callose production after induction with the pat...

Plasma homocysteine level and hepatic sulfur amino acid metabolism in mice fed a high-fat diet.

Eur. J. Nutr. 52(1) , 127-34, (2013)

Obesity, a feature of metabolic syndrome, is a risk factor for cardiovascular disease, and elevated plasma homocysteine is associated with increased cardiovascular risk. However, little published information is available concerning the effect of obesity on ho...

From cysteine to longer chain thiols: thermodynamic analysis of cadmium binding by phytochelatins and their fragments.

Metallomics 3 , 838-846, (2011)

Isothermal Titration Calorimetry (ITC) was used to study the binding of Cd(2+) by phytochelatins ((γGlu-Cys)(n)-Gly, PC(n); n = 1-5) and their selected fragments (Cys, Cys-Gly and γGlu-Cys) in order to understand the influence of the chain length on the compl...