trans-4-Carboxy-L-proline

Suppliers

Names

[ CAS No. ]:
64769-66-0

[ Name ]:
trans-4-Carboxy-L-proline

[Synonym ]:
L-trans-pyrrolidine-2,4-dicarboxylic acid
MFCD00153866
Quipazine dimaleate
trans-4-Carboxy-L-proline
t-2,4-PDC
L-trans-PDC
t-PDC

Chemical & Physical Properties

[ Density]:
1.456 g/cm3

[ Boiling Point ]:
355.3ºC at 760 mmHg

[ Molecular Formula ]:
C6H9NO4

[ Molecular Weight ]:
159.14000

[ Flash Point ]:
168.7ºC

[ Exact Mass ]:
159.05300

[ PSA ]:
86.63000

[ Index of Refraction ]:
1.534

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • N-(benzyloxycarbonyl)-cis-4-hydroxy-L-proline ethyl ester
  • N-(benzyloxycarbonyl)-trans-4-cyano-L-proline ethyl ester
  • N-(benzyloxycarbonyl)-trans-4-carboxy-L-proline dimethyl ester
  • L-Hydroxyproline
  • N-Carbobenzoxy-4-oxo-L-proline
  • Z-Hyp-OH
  • (4S)-1-[(Benzyloxy)carbonyl]-4-hydroxy-L-proline

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Evidence for a role of GABA- and glutamate-gated chloride channels in olfactory memory.

Pharmacol. Biochem. Behav. 103(1) , 69-75, (2012)

In the honeybee, we investigated the role of transmissions mediated by GABA-gated chloride channels and glutamate-gated chloride channels (GluCls) of the mushroom bodies (MBs) on olfactory learning us...

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

Bioorg. Med. Chem. Lett. 16(12) , 3268-72, (2006)

A series of substituted pyrrolidine-2,4-dicarboxylic acid amides were synthesized as potential antidiabetic agents, and many of them showed good in vitro DPP-IV inhibition (IC50 = 2-250 nM) with selec...

The effects of local perfusion of DAMGO on extracellular GABA and glutamate concentrations in the rostral ventromedial medulla.

J. Neurochem. 104(3) , 806-17, (2008)

Electrophysiological data suggest an involvement of rostral ventromedial medulla (RVM) GABA and glutamate (GLU) neurons in morphine analgesia. Direct evidence that extracellular concentrations of GABA...


More Articles

Related Compounds

  • trans-4-Carboxy-L-proline
  • N-CBZ-trans-4-carboxy-L-proline
  • N-(benzyloxycarbonyl)-trans-4-carboxy-L-proline dimethyl ester
  • N-(benzyloxycarbonyl)-cis-4-carboxy-L-proline dimethyl ester
  • cis-N-(benzyloxycarbonyl)-4-carboxy-L-proline methyl ester
  • trans-4-OTBS-L-proline
  • 3-Amino-3-(2-hydroxy-4,5-dimethylphenyl)propanoic acid
  • 2-(3-Fluoropyridin-4-yl)thiazole-5-carbaldehyde
  • 2-Fluoro-2-(oxan-4-yl)acetic acid
  • {Spiro[2.3]hexan-1-yl}methanol
  • 2-Amino-3-(2-hydroxy-4,5-dimethylphenyl)propanoic acid
  • benzyl N-[1-(4-fluorophenyl)-3-hydroxypropan-2-yl]carbamate
  • 4-(2-(bromomethyl)cyclopropyl)tetrahydro-2H-pyran
  • 4-chlorothieno[3,2-d]pyrimidine-7-carbaldehyde
  • 3-(2-(Chloromethyl)cyclopropyl)tetrahydrofuran
  • 4-Pyridinecarboximidamide, 3-[4-(cyclopropylmethyl)-1-piperazinyl]-
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