1,2-Diacetylbenzene

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Names

[ CAS No. ]:
704-00-7

[ Name ]:
1,2-Diacetylbenzene

[Synonym ]:
MFCD00008733
o-Diacetylbenzene
o-acetylacetophenone
EINECS 211-877-6
1,2-Diacetylbenzene
1,2-acetyl-benzene

Chemical & Physical Properties

[ Density]:
110 C 0.1 mm Hg(lit.)

[ Boiling Point ]:
110 °C0.1 mm Hg(lit.)

[ Melting Point ]:
39-41 °C(lit.)

[ Molecular Formula ]:
C10H10O2

[ Molecular Weight ]:
162.18500

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
162.06800

[ PSA ]:
34.14000

[ LogP ]:
2.09180

[ Index of Refraction ]:
1.519

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5782637
CHEMICAL NAME :
Ethanone, 1,1'-(1,2-phenylene)bis-
CAS REGISTRY NUMBER :
704-00-7
LAST UPDATED :
199606
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H10-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
440 mg/kg/11W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from afferent nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 11,261,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg/8W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 12,343,1992

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
KM5782637

[ HS Code ]:
29143900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • α,α'-Dimethyl-o-xylene-α,α'-diol
  • Ethanone,1-(2-ethynylphenyl)-(9CI)
  • N-salicylidene acetylhydrazine
  • 1,4-epidioxy-1,4-dimethyl-1,2,3,4-tetrahydronaphthalene
  • 1,2,4-Trimethylnaphthalene
  • 3-Hexene-2,5-dione
  • o-Phthalaldehyde

DownStream

  • 3-methylinden-1-one

Customs

[ HS Code ]: 29143900

Articles

New insights into mechanisms of gamma-diketone-induced axonopathy.

Neurochem. Res. 34(11) , 1919-23, (2009)

We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-f...

Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport.

Neurochem. Res. 32(12) , 2152-9, (2007)

The aromatic hydrocarbon 1,2-diacetylbenzene (1,2-DAB) is a protein-reactive gamma-diketone metabolite of the neurotoxic solvent 1,2-diethylbenzene (1,2-DEB). The effect of neurotoxic 1,2-DAB and its ...

Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy.

Toxicol. Appl. Pharmacol. 183(1) , 55-65, (2002)

The gamma-diketone analogs 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD), but not the delta-diketone 1,3-diacetylbenzene (1,3-DAB) or the beta-diketone 2,4-hexanedione, induce neuropathol...


More Articles

Related Compounds

  • 1-(2,4-dibenzoyloxy-5-acetylphenyl)-ethanone
  • 1,2-bis(1,3-benzothiazol-2-yl)ethane-1,2-dione
  • 1-(2-Bromoethoxy)-1,1,2,2,2-pentafluoroethane
  • 1,2-Oxathiane, 2-oxide
  • [1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]methanol
  • 1-(2,2-dibromoethenyl)-4-phenylbenzene
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpropanamido]-1-methylcyclopentane-1-carboxylic acid
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide