1,2-Diacetylbenzene

Modify Date: 2024-01-10 17:25:11

1,2-Diacetylbenzene Structure
1,2-Diacetylbenzene structure
Common Name 1,2-Diacetylbenzene
CAS Number 704-00-7 Molecular Weight 162.18500
Density 110 C 0.1 mm Hg(lit.) Boiling Point 110 °C0.1 mm Hg(lit.)
Molecular Formula C10H10O2 Melting Point 39-41 °C(lit.)
MSDS Chinese Flash Point >230 °F

 Names

Name 1-(2-acetylphenyl)ethanone
Synonym More Synonyms

 Chemical & Physical Properties

Density 110 C 0.1 mm Hg(lit.)
Boiling Point 110 °C0.1 mm Hg(lit.)
Melting Point 39-41 °C(lit.)
Molecular Formula C10H10O2
Molecular Weight 162.18500
Flash Point >230 °F
Exact Mass 162.06800
PSA 34.14000
LogP 2.09180
Index of Refraction 1.519
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KM5782637
CHEMICAL NAME :
Ethanone, 1,1'-(1,2-phenylene)bis-
CAS REGISTRY NUMBER :
704-00-7
LAST UPDATED :
199606
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C10-H10-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
440 mg/kg/11W-I
TOXIC EFFECTS :
Peripheral Nerve and Sensation - recording from afferent nerve Peripheral Nerve and Sensation - recording from peripheral motor nerve
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 11,261,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
320 mg/kg/8W-I
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 12,343,1992

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS KM5782637
HS Code 29143900

 Synthetic Route

 Customs

HS Code 29143900

 Articles15

More Articles
New insights into mechanisms of gamma-diketone-induced axonopathy.

Neurochem. Res. 34(11) , 1919-23, (2009)

We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-f...

Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport.

Neurochem. Res. 32(12) , 2152-9, (2007)

The aromatic hydrocarbon 1,2-diacetylbenzene (1,2-DAB) is a protein-reactive gamma-diketone metabolite of the neurotoxic solvent 1,2-diethylbenzene (1,2-DEB). The effect of neurotoxic 1,2-DAB and its ...

Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy.

Toxicol. Appl. Pharmacol. 183(1) , 55-65, (2002)

The gamma-diketone analogs 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD), but not the delta-diketone 1,3-diacetylbenzene (1,3-DAB) or the beta-diketone 2,4-hexanedione, induce neuropathol...

 Synonyms

MFCD00008733
o-Diacetylbenzene
o-acetylacetophenone
EINECS 211-877-6
1,2-Diacetylbenzene
1,2-acetyl-benzene