1,2-Diacetylbenzene
1,2-Diacetylbenzene structure
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Common Name | 1,2-Diacetylbenzene | ||
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| CAS Number | 704-00-7 | Molecular Weight | 162.18500 | |
| Density | 110 C 0.1 mm Hg(lit.) | Boiling Point | 110 °C0.1 mm Hg(lit.) | |
| Molecular Formula | C10H10O2 | Melting Point | 39-41 °C(lit.) | |
| MSDS | Chinese | Flash Point | >230 °F | |
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New insights into mechanisms of gamma-diketone-induced axonopathy.
Neurochem. Res. 34(11) , 1919-23, (2009) We analyzed the impact of axonopathy-inducing agents 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD) on membrane-bound protein disulfide isomerase (mPDI) versus soluble PDI (sPDI), or PDI-family member thioredoxin (THX), and asked whether changes i... |
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Axonopathy-inducing 1,2-diacetylbenzene forms adducts with motor and cytoskeletal proteins required for axonal transport.
Neurochem. Res. 32(12) , 2152-9, (2007) The aromatic hydrocarbon 1,2-diacetylbenzene (1,2-DAB) is a protein-reactive gamma-diketone metabolite of the neurotoxic solvent 1,2-diethylbenzene (1,2-DEB). The effect of neurotoxic 1,2-DAB and its non-neurotoxic isomer 1,3-DAB has been studied on motor pro... |
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Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy.
Toxicol. Appl. Pharmacol. 183(1) , 55-65, (2002) The gamma-diketone analogs 1,2-diacetylbenzene (1,2-DAB) and 2,5-hexanedione (2,5-HD), but not the delta-diketone 1,3-diacetylbenzene (1,3-DAB) or the beta-diketone 2,4-hexanedione, induce neuropathological changes in the rodent central and peripheral nervous... |
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A fluorometric assay for biotinidase.
Anal. Biochem. 154 , 282, (1986) An assay for biotinidase using biocytin, the natural substrate, is described. The fluorometric procedure uses 1,2-diacetylbenzene which reacts selectively with lysine allowing its direct determination in mixture with biocytin. We have examined the applicabili... |
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Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane.
Toxicol. Sci. 107(2) , 482-9, (2009) Neuroprotein changes in the spinal cord of rodents with aliphatic gamma-diketone axonopathy induced by 2,5-hexanedione (2,5-HD) are compared with those reported previously in aromatic gamma-diketone-like axonopathy induced by 1,2-diacetylbenzene (1,2-DAB). Sp... |
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Theoretical determination of chromophores in the chromogenic effects of aromatic neurotoxicants.
J. Am. Chem. Soc. 124(11) , 2744-52, (2002) We report the first computational study of the chromophores responsible for the chromogenic effects of aromatic neurotoxicants containing a 1,2-diacetyl moiety in their oxidation metabolites. A series of ab initio electronic structure calculations was perform... |
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1,2-diacetylbenzene, the neurotoxic metabolite of a chromogenic aromatic solvent, induces proximal axonopathy.
Toxicol. Appl. Pharmacol. 177(2) , 121-31, (2001) Several widely used aromatic hydrocarbon solvents reportedly induce blue-green discoloration of tissues and urine in animals and humans. The chomophore has been proposed to result from a ninhydrin-like reaction with amino groups in proteins. The present study... |
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Possible involvement of 1,2-diacetylbenzene in diethylbenzene-induced neuropathy in rats.
J. Appl. Toxicol. 11(4) , 261-8, (1991) The role of 1,2-diacetylbenzene (1,2-DAB) in the peripheral nerve toxicity of 1,2-diethylbenzene (1,2-DEB) was investigated in rats. Gas chromatography-mass spectrometry identified 1,2-DAB in the urine samples of rats given 165 mg kg-1 1,2-DEB orally on four ... |
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Probing mechanisms of axonopathy. Part I: Protein targets of 1,2-diacetylbenzene, the neurotoxic metabolite of aromatic solvent 1,2-diethylbenzene.
Toxicol. Sci. 105(1) , 134-41, (2008) Motor neuron axonopathy in diseases such as amyotrophic lateral sclerosis can be modeled and probed with neurotoxic chemicals that induce similar patterns of pathology, such as axonal spheroids that represent focal accumulation of anterogradely transported ne... |
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Alteration of brainstem auditory evoked potentials in diethylbenzene and diacetylbenzene-treated rats.
J. Appl. Toxicol. 12(5) , 343-50, (1992) Male Sprague-Dawley rats were treated either with 1,2-diethylbenzene (1,2-DEB) or its putative active metabolite, 1,2-diacetylbenzene (1,2-DAB). Experimental rats and appropriate controls were examined electrophysiologically for brainstem auditory evoked pote... |