Chloroxine

Names

[ CAS No. ]:
773-76-2

[ Name ]:
Chloroxine

[Synonym ]:
5,7-Dichloro-8-quinolinol
5,7-Dichloro-8-hydroxyquinoline
EINECS 212-258-3
Chloroxine
5,7-dichloroquinolin-8-ol
8-Quinolinol, 5,7-dichloro-
MFCD00006786

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
354.7±37.0 °C at 760 mmHg

[ Melting Point ]:
178-180 °C(lit.)

[ Molecular Formula ]:
C₉H₅Cl₂NO

[ Molecular Weight ]:
214.048

[ Flash Point ]:
168.3±26.5 °C

[ Exact Mass ]:
212.974823

[ PSA ]:
33.12000

[ LogP ]:
3.75

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.702

[ Storage condition ]:
2-8°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC5350000

CHEMICAL NAME :: 8-Quinolinol, 5,7-dichloro-

CAS REGISTRY NUMBER :: 773-76-2

BEILSTEIN REFERENCE NO. :: 0153606

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H5-Cl2-N-O

MOLECULAR WEIGHT :: 214.05

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 100 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 307,141,1994

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39-S25-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
VC5350000

[ HS Code ]:
2933499090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

8-Hydroxyquinoline
5,7,7-trichloro-7H-quinoline-8-one
2,4-Dichloro-6-nitrophenol
Glycerol
1,4-Dioxane
Clioquinol
Water

DownStream

5,7-Dichloro-8-quinolinol benzoate (ester)
β-D-Glucopyranose
5-Chloro-8-hydroxyquinoline
5,7-dichloroquinolin-8-amine

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.

Org. Lett. 16(3) , 864-7, (2014)

A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of cop...

Reverse-phase high-performance liquid chromatographic determination of halogenated 8-hydroxyquinoline compounds in pharmaceuticals and bulk drugs.

J. Pharm. Sci. 73(10) , 1430-3, (1984)

A reverse-phase high-performance liquid chromatographic (HPLC) method was developed for determining iodochlorhydroxyquin, 5,7-dichloro-8-hydroxyquinoline, and 5,7-diiodo-8-hydroxyquinoline in creams, ...

Effects of chlorhexidine, iodine, and 5,7-dichloro-8-hydroxyquinoline on the bacterial composition of rat plaque in vivo.

Caries Res. 18(5) , 440-6, (1984)

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(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
methyl 5-bromo-2-chloro-1H-1,3-benzodiazole-7-carboxylate