Chloroxine
Chloroxine structure
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Common Name | Chloroxine | ||
|---|---|---|---|---|
| CAS Number | 773-76-2 | Molecular Weight | 214.048 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 354.7±37.0 °C at 760 mmHg | |
| Molecular Formula | C9H5Cl2NO | Melting Point | 178-180 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 168.3±26.5 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
Use of ChloroxineChloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.Target: AntibacterialChloroxine is an antibacterial drug. Oral formulations are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis, as used in shampoos and dermal creams like. Chloroxine has bacteriostatic, fungistatic and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella and Trichomonads. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | chloroxine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Chloroxine is a synthetic antibacterial compound that is effective in the treatment of dandruff and seborrheic dermatitis when incorporated in a shampoo.Target: AntibacterialChloroxine is an antibacterial drug. Oral formulations are used in infectious diarrhea, disorders of the intestinal microflora (e.g. after antibiotic treatment), giardiasis, inflammatory bowel disease. It is also useful for dandruff and seborrheic dermatitis, as used in shampoos and dermal creams like. Chloroxine has bacteriostatic, fungistatic and antiprotozoal properties. It is effective against Streptococci, Staphylococci, Candida, Candida albicans, Shigella and Trichomonads. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 354.7±37.0 °C at 760 mmHg |
| Melting Point | 178-180 °C(lit.) |
| Molecular Formula | C9H5Cl2NO |
| Molecular Weight | 214.048 |
| Flash Point | 168.3±26.5 °C |
| Exact Mass | 212.974823 |
| PSA | 33.12000 |
| LogP | 3.75 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.702 |
| InChIKey | WDFKMLRRRCGAKS-UHFFFAOYSA-N |
| SMILES | Oc1c(Cl)cc(Cl)c2cccnc12 |
| Storage condition | 2-8°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS05, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H315-H318-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S37/39-S25-S22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | VC5350000 |
| HS Code | 2933499090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Chloroxine CAS#:773-76-2 |
| Literature: Dalton Transactions, , vol. 42, # 6 p. 2023 - 2034 |
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Chloroxine CAS#:773-76-2 |
| Literature: Chemische Berichte, , vol. 21, p. 2979,2983 |
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Chloroxine CAS#:773-76-2 |
| Literature: Chemische Berichte, , vol. 21, p. 2979,2983 |
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Chloroxine CAS#:773-76-2
Learn More
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| Literature: Journal of the Indian Chemical Society, , vol. 22, p. 171 |
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Chloroxine CAS#:773-76-2 |
| Literature: Journal of the Indian Chemical Society, , vol. 21, p. 354,356 |
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Chloroxine CAS#:773-76-2
Detail
Learn More
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| Literature: Chemische Berichte, , vol. 85, p. 104,106 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
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| DownStream 4 | |
CAS#:18193-10-7
CAS#:36107-01-4This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides.
Org. Lett. 16(3) , 864-7, (2014) A one-step transformation of heterocyclic N-oxides to 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles is described. The success of this broad-scope methodology hinges on the combination of cop... |
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Reverse-phase high-performance liquid chromatographic determination of halogenated 8-hydroxyquinoline compounds in pharmaceuticals and bulk drugs.
J. Pharm. Sci. 73(10) , 1430-3, (1984) A reverse-phase high-performance liquid chromatographic (HPLC) method was developed for determining iodochlorhydroxyquin, 5,7-dichloro-8-hydroxyquinoline, and 5,7-diiodo-8-hydroxyquinoline in creams, ... |
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Effects of chlorhexidine, iodine, and 5,7-dichloro-8-hydroxyquinoline on the bacterial composition of rat plaque in vivo.
Caries Res. 18(5) , 440-6, (1984)
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This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 5,7-Dichloro-8-quinolinol |
| 5,7-Dichloro-8-hydroxyquinoline |
| EINECS 212-258-3 |
| Chloroxine |
| 5,7-dichloroquinolin-8-ol |
| MFCD00006786 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the boiling point of chloroxine? |
| A: Boiling point of chloroxine is 354.7±37.0 °C at 760 mmHg. |
| Q: What is the SMILES notation of chloroxine? |
| A: SMILES notation of chloroxine is Oc1c(Cl)cc(Cl)c2cccnc12. |
| Q: What is the polar surface area (PSA) of chloroxine? |
| A: Polar surface area (PSA) of chloroxine is 33.12000. |
| Q: What is the CAS number of chloroxine? |
| A: CAS number of chloroxine is 773-76-2. |
| Q: What is the melting point of chloroxine? |
| A: Melting point of chloroxine is 178-180 °C(lit.). |
| Q: What is the safety information for chloroxine? |
| A: Safety information for chloroxine: S26-S36-S37/39-S25-S22. |
| Q: What are the downstream products of chloroxine? |
| A: Related downstream products(CAS) of chloroxine: 18193-10-7;492-61-5;130-16-5;36107-01-4. |
| Q: What are the upstream materials of chloroxine? |
| A: Related upstream materials(CAS) of chloroxine: 148-24-3;687638-05-7;609-89-2;56-81-5;123-91-1;130-26-7;7732-18-5. |
| Q: What is the molecular weight of chloroxine? |
| A: Molecular weight of chloroxine is 214.048. |
| Q: What is the molecular formula of chloroxine? |
| A: Molecular formula of chloroxine is C9H5Cl2NO. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |