2,6-xylidine
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Names
[ CAS No. ]:
87-62-7
[ Name ]:
2,6-xylidine
[Synonym ]:
o-Xylidine
2-Amino-1,3-xylene
2,6-dimethyl-aniline
Benzene, 2-amino-1,3-dimethyl-
1-amino-2,6-dimethybenzene
Benzenamine,2,6-dimethyl
2,6-xylidine
2,6-dimethylphenylamine
2,6-dimethylbenzeneamine
aniline, 2,6-dimethyl-
MFCD00007747
2-amino-1,3-dimethylbenzene
Benzenamine, 2,6-dimethyl-
2,6-Dimethylbenzenamine
2,6-Dimethylaniline
2-Amino-m-xylene
2,5-DIMETHOXYTOLUENE
1-amino-2,6-dimethylbenzene
2,6-methylaniline
EINECS 201-758-7
2,6-dimethyl aniline
Bupivacaine Impurity 8
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
217.9±0.0 °C at 760 mmHg
[ Melting Point ]:
10-12 °C(lit.)
[ Molecular Formula ]:
C8H11N
[ Molecular Weight ]:
121.180
[ Flash Point ]:
91.1±0.0 °C
[ Exact Mass ]:
121.089149
[ PSA ]:
26.02000
[ LogP ]:
1.86
[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.559
[ Water Solubility ]:
7.5 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ZE9275000
- CHEMICAL NAME :
- 2,6-Xylidine
- CAS REGISTRY NUMBER :
- 87-62-7
- BEILSTEIN REFERENCE NO. :
- 0636332
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 19
- MOLECULAR FORMULA :
- C8-H11-N
- MOLECULAR WEIGHT :
- 121.20
- WISWESSER LINE NOTATION :
- ZR B1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 840 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis Blood - changes in spleen
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 707 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3150 mg/kg/20D-C
- TOXIC EFFECTS :
- Blood - changes in spleen
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6200 mg/kg/2W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 13300 mg/kg/4W-I
- TOXIC EFFECTS :
- Liver - other changes Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20150 mg/kg/13W-I
- TOXIC EFFECTS :
- Brain and Coverings - changes in brain weight Liver - changes in liver weight Blood - changes in other cell count (unspecified)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 107 gm/kg/2Y-C
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Endocrine - tumors
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 301 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 57,323,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7951 No. of Facilities: 21 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4354 (estimated) No. of Female Employees: 729 (estimated)
Safety Information
[ Symbol ]:
GHS07, GHS08, GHS09
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302 + H312 + H332-H315-H335-H351-H411
[ Precautionary Statements ]:
P261-P273-P280
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;N:Dangerousfortheenvironment;
[ Risk Phrases ]:
R20/21/22;R37/38;R40;R51/53
[ Safety Phrases ]:
S23-S25-S36/37-S61
[ RIDADR ]:
UN 1711 6.1/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
ZE9275000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
29214910
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2921430090
[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%
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