2,6-xylidine
2,6-xylidine structure
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Common Name | 2,6-xylidine | ||
|---|---|---|---|---|
| CAS Number | 87-62-7 | Molecular Weight | 121.180 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 217.9±0.0 °C at 760 mmHg | |
| Molecular Formula | C8H11N | Melting Point | 10-12 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 91.1±0.0 °C | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Warning | |
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Simultaneous Determination of Xylazine and 2,6-Xylidine in Blood and Urine by Auto Solid-Phase Extraction and Ultra High Performance Liquid Chromatography Coupled with Quadrupole-Time of Flight Mass Spectrometry.
J. Anal. Toxicol. 39 , 444-50, (2015) Xylazine as veterinary medicine for sedation, but intoxication cases in humans were identified in the last few years. A highly sensitive method is required for analyzing xylazine and its metabolites in human blood and urine. This article presents an ultra hig... |
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A Novel Method for Assessing Drug Degradation Product Safety Using Physiologically-Based Pharmacokinetic Models and Stochastic Risk Assessment.
J. Pharm. Sci. 104 , 3101-19, (2015) Patient safety risk due to toxic degradation products is a potentially critical quality issue for a small group of useful drug substances. Although the pharmacokinetics of toxic drug degradation products may impact product safety, these data are frequently un... |
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Concentrations of dimethylaniline and other metabolites in milk and tissues of dairy cows treated with lidocaine.
Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 32 , 1256-64, (2015) Lidocaine is a topical anaesthetic drug used in dairy cows for laparotomy (caesarean section, abomasal displacement). Because there are no registered drugs for this indication, it can be applied under the so-called Cascade rules (off-label use), with the rest... |
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Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase.
Drug Metab. Dispos. 42(7) , 1103-9, (2014) Esterases catalyze the hydrolysis of therapeutic drugs containing esters or amides in their structures. Human carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes that catalyze the hydrolysis of drugs in the liver. Characterizati... |
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Separation and analysis of dimethylaniline isomers by supercritical fluid chromatography—Electrospray ionization tandem mass spectrometry
J. Chromatogr. A. 1216(41) , 6970-3, (2009) The assessment of human exposure to specific isomers of dimethylanilines (DMA's) is of interest for the evaluation of potential exposure-health outcome relationships. Improved analytical methods will help in identifying the environmental sources of such expos... |
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Retention time prediction of compounds in Grob standard mixture for apolar capillary columns in temperature-programmed gas chromatography.
Anal. Bioanal. Chem 393(1) , 327-34, (2009) This paper presents an extension of a previous investigation in which the behavior of nonpolar compounds in temperature-programmed gas chromatographic runs was predicted using thermodynamic (entropy and enthalpy) parameters derived from isothermal runs. In a ... |
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Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2-methylaniline, for DNA adduct formation in rat tissues.
Drug Metab. Dispos. 36(8) , 1470-5, (2008) The local anesthetics lidocaine (lido) and prilocaine (prilo) are metabolized to their constituent aromatic amines 2,6-dimethylaniline (DMA, 2,6-xylidine) and 2-methylaniline (MA, o-toluidine), respectively, which are both tumorigenic in rats. The capacity of... |
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Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species.
Toxicol. Sci. 130(1) , 48-59, (2012) Several alkylanilines with structures more complex than toluidines have been associated epidemiologically with human cancer. Their mechanism of action remains largely undetermined, and there is no reported evidence that it replicates that of multicyclic aroma... |
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Metabolic activation of 2,6-xylidine in the nasal olfactory mucosa and the mucosa of the upper alimentary and respiratory tracts in rats.
Toxicol. Sci. 81(2) , 263-72, (2004) Whole-body low-temperature radioluminography of (3)H-2,6-xylidine in rats indicates that the nonmetabolized substance, which is a volatile and fat-soluble compound, is distributed throughout the body and accumulates in adipose tissues, e.g., in the abdominal ... |
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Changes in production of lignin degrading enzymes during interactions between mycelia of the tropical decomposer basidiomycetes Marasmiellus troyanus and Marasmius pallescens.
Mycol. Res. 110(Pt 2) , 161-8, (2006) During the interaction of two tropical agaric fungi, Marasmius pallescens and Marasmiellus troyanus, on agar media, initial deadlock between the two mycelia was ultimately followed by take-over by M. troyanus. When shaken liquid cultures of these two fungi we... |