edaravone
Suppliers
Names
[ CAS No. ]:
89-25-8
[ Name ]:
edaravone
[Synonym ]:
1-PHENYL-3-METHYL-5-PYRAZALONE
3-methyl-1-phenyl-1H-pyrazol-5(4H)-one
2,4-dihydro-5-methyl-2-phenyl-3h-pyrazol-3-one
5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
3-methyl-1-phenyl-4,5-dihydro-1H-pyrazol-5-one
1-PHENYL-3-METHYL-5-PYRAZOLONE
1-PHENYL-3-METHYL-5-PYRAZOLE
3-METHYL-1-PHENYL-2-PYRAZOLIN-5ONE
MFCD00003138
1-PHENYL-3-METHYL-5- PYRAZOLONE
3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE FOR SYNTHESIS
3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ON
3-Methyl-1-phenyl-2-pyrazolin-5-one
3-Methyl-1-phenyl-5-pyrazolone
c.i. developer 1
3-Methyl-1-phenyl-2-pyrazoline-5-one
3-METHYL-1-PHENYL-2-PYRAZOLINE-5-ONE / EDARAVONE
1-PHENYL-3-METHYL-5-OXO-2-PYRAZOLINE
1-PHENYL-3-METHYL-2-PYRAZOLIN-5-ONE
Edaravone (MCI-186)
5-METHYL-2-PHENYL-1,2-DIHYDROPYRAZOL-3-ONE EDARAVONE
3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE (EDARAVONE)
1-pheny-3-methyl-5-pyrazolone (PMP)
5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one
EINECS 201-891-0
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
333.0±11.0 °C at 760 mmHg
[ Melting Point ]:
126-128 °C(lit.)
[ Molecular Formula ]:
C10H10N2O
[ Molecular Weight ]:
174.199
[ Flash Point ]:
155.2±19.3 °C
[ Exact Mass ]:
174.079315
[ PSA ]:
32.67000
[ LogP ]:
0.44
[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C
[ Index of Refraction ]:
1.606
[ Storage condition ]:
Store at RT
[ Water Solubility ]:
3 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ9625000
- CHEMICAL NAME :
- 2-Pyrazolin-5-one, 3-methyl-1-phenyl-
- CAS REGISTRY NUMBER :
- 89-25-8
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C10-H10-N2-O
- MOLECULAR WEIGHT :
- 174.22
- WISWESSER LINE NOTATION :
- T5NMV DHJ BR& E1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3500 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2012 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TYPE OF TEST :
- Specific locus test
- TEST SYSTEM :
- Rodent - mouse Lymphocyte
- DOSE/DURATION :
- 300 mg/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 17,196,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83422 No. of Facilities: 11 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 114 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83422 No. of Facilities: 62 (estimated) No. of Industries: 5 No. of Occupations: 5 No. of Employees: 580 (estimated) No. of Female Employees: 137 (estimated)
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
S26-S36
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
1
[ RTECS ]:
UQ9625000
[ HS Code ]:
2933199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933199090
[ Summary ]:
2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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