edaravone
edaravone structure
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Common Name | edaravone | ||
|---|---|---|---|---|
| CAS Number | 89-25-8 | Molecular Weight | 174.199 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 333.0±11.0 °C at 760 mmHg | |
| Molecular Formula | C10H10N2O | Melting Point | 126-128 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 155.2±19.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.
Leuk. Lymphoma 56(3) , 739-47, (2015) The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity and mechanism of a p53 reactivator, ellipticine, in a cellul... |
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The free radical scavenger, edaravone, ameliorates delayed neuropsychological sequelae after acute carbon monoxide poisoning in rabbits.
Undersea Hyperb. Med. 40(3) , 223-9, (2013) The mechanism underlying delayed neuropsychological sequelae (DNS) after acute carbon monoxide (CO) poisoning is unclear. There are no effective treatments for DNS. As part of a new generation of antioxidants, edaravone has been reported to improve clinical o... |
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Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells.
Neurosci. Lett. 531(2) , 160-5, (2012) Oxidative stress has been demonstrated to be involved in the pathogenesis of Alzheimer's disease (AD). Thus, antioxidant therapy may represent a promising avenue for the treatment of AD. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent free radical... |
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Edaravone alleviates hypoxia-acidosis/reoxygenation-induced neuronal injury by activating ERK1/2
Neurosci. Lett. 543 , 72-7, (2013) • Hypoxia-acidosis/reoxygenation (H-A/R) exposure triggers neuronal injury. • Edaravone alleviates H-A/R-induced neuronal injury. • ERK1/2 activation is involved in the process of edaravone neuroprotection. |
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Ultrasound-promoted greener synthesis of novel trifurcate 3-substituted-chroman-2,4-dione derivatives and their drug-likeness evaluation.
Molecules 17(12) , 14146-58, (2012) An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy-coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this met... |
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Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
J. Pharm. Pharmacol. 65(1) , 102-14, (2013) To establish whether aminophylline, administered at usual doses for rodents in pharmacological studies, induces brain injury in systemic hypoxaemia in guinea-pigs. A hypoxaemia (partial oxygen tension of arterial blood (PaO₂) = 40-60 mmHg) model was developed... |
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Beneficial effects of edaravone on the expression of serum matrix metalloproteinase-9 after cerebral hemorrhage.
Neurosciences (Riyadh.) 19(2) , 106-10, (2014) To explore the effects of edaravone on the expression of matrix metalloproteinase-9 (MMP-9) posterior to cerebral hemorrhage, and to analyze the relationship between this expression and neurological deficit.A total of 160 basal ganglia hemorrhage patients enr... |
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Role of nitric oxide in the onset of facial nerve palsy by HSV-1 infection.
JAMA Otolaryngol. Head Neck Surg. 139(12) , 1339-42, (2013) Although herpes simplex virus type 1 (HSV-1) is a causative agent of Bell palsy, the precise mechanism of the paralysis remains unknown. It is necessary to investigate the pathogenesis and treatment of Bell palsy due to HSV-1 infection.This study elucidated t... |
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Pure sensory deficit at the T3 sensory level as an isolated manifestation of lateral medullary infarction.
Neurol. India 61(3) , 327-8, (2013)
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Edaravone may be an efficacious adjunctive therapeutic agent for decompression sickness: an editorial perspective.
Undersea Hyperb. Med. 40(3) , 215-7, (2013)
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