O-Desmethylvenlafaxine

Suppliers

Names

[ Name ]:
O-Desmethylvenlafaxine

[Synonym ]:
Phenol, 4-[2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]-
desvenlafaxine
O-Desmethylvenlafaxine
L6TJ AYR DQ&1N1&1 AQ
4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol
4-(2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
403.8±25.0 °C at 760 mmHg

[ Melting Point ]:
208-213ºC

[ Molecular Formula ]:
C₁₆H₂₅NO₂

[ Molecular Weight ]:
263.375

[ Flash Point ]:
193.2±21.8 °C

[ Exact Mass ]:
263.188538

[ PSA ]:
43.70000

[ LogP ]:
2.26

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.573

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T,Xi

[ Risk Phrases ]:
11-23/24/25-39/23/24/25-36

[ Safety Phrases ]:
7-16-36/37-45-26

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ RTECS ]:
GV8872620

[ HS Code ]:
2922509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-[1-(4-Benzyloxyphenyl)-2-(dimethylamino)ethyl]cyclohexanol
Venlafaxine
O-(4-methoxybenzyl)desvenlafaxine
Venlafaxine hydrochloride
2-(1-hydroxycyclohexyl)-2-(4-hydroxyphenyl)acetonitrile
Dimethylamine
Formic Acid
5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane hydroc hloride
N,N,O-Tridesmethylvenlafaxine

DownStream

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015)

Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix c...

Hollow-fiber liquid-phase microextraction and chiral LC-MS/MS analysis of venlafaxine and its metabolites in plasma.

Bioanalysis 5(6) , 721-30, (2013)

An enantioselective analytical method was developed and validated for determination of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in plasma samples. The method e...

A poor metabolizer of both CYP2C19 and CYP2D6 identified by mechanistic pharmacokinetic simulation in a fatal drug poisoning case involving venlafaxine.

Forensic Sci. Int. 226(1-3) , e26-31, (2013)

We present a fatal drug poisoning case involving venlafaxine (VEN). The deceased took his medication regularly (including 150 mg VEN twice daily), and nothing in the case or autopsy findings pointed t...