O-Desmethylvenlafaxine
O-Desmethylvenlafaxine structure
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Common Name | O-Desmethylvenlafaxine | ||
|---|---|---|---|---|
| CAS Number | 93413-62-8 | Molecular Weight | 263.375 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 403.8±25.0 °C at 760 mmHg | |
| Molecular Formula | C16H25NO2 | Melting Point | 208-213ºC | |
| MSDS | N/A | Flash Point | 193.2±21.8 °C | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Evaluation of the matrix effect of different sample matrices for 33 pharmaceuticals by post-column infusion.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1000 , 84-94, (2015) Matrix effects that occur during quantitative measurement by liquid chromatography mass spectrometry specifically when using electrospray ionization are a widely recognized phenomenon. Sample matrix compounds affect the ionization process of the target analyt... |
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Hollow-fiber liquid-phase microextraction and chiral LC-MS/MS analysis of venlafaxine and its metabolites in plasma.
Bioanalysis 5(6) , 721-30, (2013) An enantioselective analytical method was developed and validated for determination of venlafaxine and its metabolites O-desmethylvenlafaxine and N-desmethylvenlafaxine in plasma samples. The method employed LC-MS/MS analysis and hollow-fiber liquid-phase mic... |
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A poor metabolizer of both CYP2C19 and CYP2D6 identified by mechanistic pharmacokinetic simulation in a fatal drug poisoning case involving venlafaxine.
Forensic Sci. Int. 226(1-3) , e26-31, (2013) We present a fatal drug poisoning case involving venlafaxine (VEN). The deceased took his medication regularly (including 150 mg VEN twice daily), and nothing in the case or autopsy findings pointed towards suicide. The toxicological assessment concluded that... |
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Medical school gift restriction policies and physician prescribing of newly marketed psychotropic medications: difference-in-differences analysis.
BMJ 346 , f264, (2013) To examine the effect of attending a medical school with an active policy on restricting gifts from representatives of pharmaceutical and device industries on subsequent prescribing behavior.Difference-in-differences approach.14 US medical schools with an act... |
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Effects of desvenlafaxine on the pharmacokinetics of desipramine in healthy adults.
Int. Clin. Psychopharmacol. 28(2) , 99-105, (2013) The results of two single-center, two-period, open-label trials that evaluated the effects of multiple doses of desvenlafaxine on the pharmacokinetics of desipramine, a cytochrome P450 (CYP) 2D6 enzyme substrate, are presented. Healthy individuals aged 18-45 ... |
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An evaluation of sexual functioning in employed outpatients with major depressive disorder treated with desvenlafaxine 50 mg or placebo.
J. Sex. Med. 10(3) , 768-76, (2013) The symptoms of major depressive disorder (MDD) include sexual dysfunction, but antidepressant pharmacotherapies are also associated with treatment-emergent sexual dysfunction.These secondary and post hoc analyses evaluated sexual functioning in employed adul... |
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Duloxetine versus other anti-depressive agents for depression.
Cochrane Database Syst. Rev. 10 , CD006533, (2012) Although pharmacological and psychological interventions are both effective for major depression, in primary and secondary care settings antidepressant drugs remain the mainstay of treatment. Amongst antidepressants many different agents are available. Duloxe... |
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Efficacy and safety of desvenlafaxine 25 and 50▒mg/day in a randomized, placebo-controlled study of depressed outpatients.
J. Psychiatr. Pract. 19(1) , 5-14, (2013) This study evaluated the efficacy and safety of low-dose desvenlafaxine (administered as desvenlafaxine succinate) in treating major depressive disorder (MDD).Adult outpatients (aged 18 years) in the United States and (aged 20 years) in Japan, who met Diagnos... |
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The effect of age, sex, smoking and co-medication on serum levels of venlafaxine and O-desmethylvenlafaxine under naturalistic conditions.
Pharmacopsychiatry 45(6) , 229-35, (2012) Venlafaxine (VEN) is a modern antidepressant which exerts both serotonin and norepinephrine reuptake inhibition. In this study we examined the influence of age, sex, smoking, and co-medication on serum levels of VEN and its metabolite O-desmethylvenlafaxine (... |
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Occurrence of Tako-Tsubo cardiomyopathy in association with ingestion of serotonin/noradrenaline reuptake inhibitors.
Heart. Lung Circ. 21(4) , 203-5, (2012) Tako-Tsubo cardiomyopathy (TTC) occurs particularly in post-menopausal women, being precipitated in many cases by severe emotional stress. We describe six patients in whom TTC occurred in association with therapeutic ingestion or overdose of the serotonin/nor... |