K-252a

Suppliers

Names

[ Name ]:
K-252a

[Synonym ]:
antibiotick252a
PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP.
PROTEIN KINASE INHIBITOR K-252A
PROTEIN KINASE INHIBITOR
K252a
K-252A,NOCARDIOPSIS SP
K-252a
Methyl (15S,16R,18R)-16-hydroxy-15-methyl-3-oxo-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1.0.0.0.0.0]octacosa-1,6,8,10,12,20,22,24,26-nonaene-16-carboxylate
6,9-Epoxy-15H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-7-carboxylic acid, 6,7,8,9,16,17-hexahydro-7-hydroxy-6-methyl-15-oxo-, methyl ester, (6S,7R,9R)-
antibioticsf2370
sf2370

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
685.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₇H₂₁N₃O₅

[ Molecular Weight ]:
467.473

[ Flash Point ]:
368.2±31.5 °C

[ Exact Mass ]:
467.148132

[ PSA ]:
94.72000

[ LogP ]:
4.23

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.841

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KC6500000

CAS REGISTRY NUMBER :: 99533-80-9

LAST UPDATED :: 199212

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C27-H21-N3-O5

MOLECULAR WEIGHT :: 467.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 38,1437,1985

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H360D-H371

[ Precautionary Statements ]:
P201-P260-P308 + P311

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NZ0550000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Dimethyl sulfate
K252b
(5S,8R)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6,13-dione
13-((2R,4S,5S)-4-hydroxy-5-(iodomethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
13-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
(3S,5R)-2-methylene-5-(7-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)tetrahydrofuran-3-yl acetate
(5S,6S,8R)-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-6-yl acetate

DownStream

Lestaurtinib
KT5823

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1-(2-methoxyethyl)-1H-1,2,3-benzotriazol-4-amine
2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[3-(methoxycarbonyl)phenyl]propanoic acid
rel-benzyl N-{[(4R)-4-methyl-2,5-dioxoimidazolidin-4-yl]methyl}carbamate
6-fluoro-1-(3-methoxybutyl)-1H-1,2,3-benzotriazole-7-carbonitrile
tert-butyl 3-(5-amino-6-fluoro-1H-1,2,3-benzotriazol-1-yl)pyrrolidine-1-carboxylate
tert-butyl 2-[(5-amino-6-fluoro-1H-1,2,3-benzotriazol-1-yl)methyl]piperidine-1-carboxylate
6-fluoro-1-(3-methoxybutyl)-1H-1,2,3-benzotriazol-5-amine
6-bromo-5-fluoro-1-(3-methoxybutyl)-1H-1,2,3-benzotriazole
tert-butyl 3-(7-bromo-4-methoxy-1H-1,2,3-benzotriazol-1-yl)azetidine-1-carboxylate
tert-butyl 4-[(7-bromo-4-methoxy-1H-1,2,3-benzotriazol-1-yl)methyl]piperidine-1-carboxylate

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