Hydroxy Bosentan-d4

Modify Date: 2024-01-09 23:15:15

Hydroxy Bosentan-d4 Structure
Hydroxy Bosentan-d4 structure
Common Name Hydroxy Bosentan-d4
CAS Number 1065472-91-4 Molecular Weight 571.64
Density N/A Boiling Point N/A
Molecular Formula C27H25D4N5O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Hydroxy Bosentan-d4


Hydroxy Bosentan-d4 is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

 Names

Name 4-(1-hydroxy-2-methylpropan-2-yl)-N-[5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-6-(1,1,2,2-tetradeuterio-2-hydroxyethoxy)pyrimidin-4-yl]benzenesulfonamide
Synonym More Synonyms

 Hydroxy Bosentan-d4 Biological Activity

Description Hydroxy Bosentan-d4 is deuterium labeled Hydroxy bosentan. Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8.

 Chemical & Physical Properties

Molecular Formula C27H25D4N5O7S
Molecular Weight 571.64
Exact Mass 571.20400
PSA 174.26000
LogP 4.33010

 Synonyms

Ro 48-8634-d4
Hydroxy Bosentan-d4
Ro 48-5033-d4