Hydroxy Desmethyl Bosentan
Modify Date: 2024-01-10 13:33:40
Hydroxy Desmethyl Bosentan structure
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Common Name | Hydroxy Desmethyl Bosentan | ||
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| CAS Number | 253688-62-9 | Molecular Weight | 553.58700 | |
| Density | 1.426g/cm3 | Boiling Point | 782ºC at 760 mmHg | |
| Molecular Formula | C26H27N5O7S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 426.7ºC | |
Use of Hydroxy Desmethyl BosentanHydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2]. |
| Name | N-[6-(2-hydroxyethoxy)-5-(2-hydroxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]-4-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide |
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| Synonym | More Synonyms |
| Description | Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver[1]. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension[2]. |
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| Related Catalog | |
| References |
| Density | 1.426g/cm3 |
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| Boiling Point | 782ºC at 760 mmHg |
| Molecular Formula | C26H27N5O7S |
| Molecular Weight | 553.58700 |
| Flash Point | 426.7ºC |
| Exact Mass | 553.16300 |
| PSA | 185.26000 |
| LogP | 4.02710 |
| Vapour Pressure | 9.41E-26mmHg at 25°C |
| Index of Refraction | 1.643 |
| Hydroxy Desmethyl Bosentan |
| Bosentan Impurity 3 |