Hydroxy bosentan

Modify Date: 2024-01-10 11:51:34

Hydroxy bosentan structure	Common Name	Hydroxy bosentan
	CAS Number	253688-60-7	Molecular Weight	567.61300
	Density	1.372g/cm3	Boiling Point	783.9ºC at 760 mmHg
	Molecular Formula	C₂₇H₂₉N₅O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	427.9ºC

Use of Hydroxy bosentan

Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].

Name	N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]-4-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide
Synonym	More Synonyms

Description	Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities[1].
Related Catalog	Research Areas >> Cardiovascular Disease
Target	Human Endogenous Metabolite
References	[1]. Chen M, et al. Comparison of the inhibitory effect of ketoconazole, voriconazole, fluconazole, and itraconazoleon the pharmacokinetics of bosentan and its corresponding active metabolite hydroxy bosentanin rats. Xenobiotica. 2019 Jul 3:1-8.

Density	1.372g/cm3
Boiling Point	783.9ºC at 760 mmHg
Molecular Formula	C₂₇H₂₉N₅O₇S
Molecular Weight	567.61300
Flash Point	427.9ºC
Exact Mass	567.17900
PSA	174.26000
LogP	4.33010
Vapour Pressure	7.01E-26mmHg at 25°C
Index of Refraction	1.619

4-(2-Hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide

Hydroxy Bosentan

Ro 48-8634

Benzenesulfonamide,4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]

Ro 48-5033

Bosentan Impurity 2

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Hydroxy bosentan
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Hydroxy bosentan
Price: $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Hydroxy bosentan
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

Get all suppliers and price by the below link:

Hydroxy bosentan suppliers

Hydroxy bosentan price