AK 295

Modify Date: 2024-02-25 11:21:17

AK 295 Structure
AK 295 structure
Common Name AK 295
CAS Number 160399-35-9 Molecular Weight 504.62
Density 1.145g/cm3 Boiling Point N/A
Molecular Formula C26H40N4O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AK 295


AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis[1].

 Names

Name benzyl N-[(2S)-4-methyl-1-[[1-(3-morpholin-4-ylpropylamino)-1,2-dioxopentan-3-yl]amino]-1-oxopentan-2-yl]carbamate
Synonym More Synonyms

 AK 295 Biological Activity

Description AK 295 (CX 295) is a calpain inhibitor that inhibits apoptosis through a calpain-dependent pathway. AK 295 improves neurological function in a rat model of spinal cord injury (SCI). AK 295 can be used in the study of neurodegenerative diseases, such as bulbar amyotrophy, stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis[1].
Related Catalog
Target

Calpain[1].

References

[1]. Colak A, et al. Calpain inhibitor AK 295 inhibits calpain-induced apoptosis and improves neurologic function after traumatic spinal cord injury in rats. Neurocirugia (Astur). 2009 Jun;20(3):245-54.  

 Chemical & Physical Properties

Density 1.145g/cm3
Molecular Formula C26H40N4O6
Molecular Weight 504.62
Exact Mass 504.29500
PSA 133.05000
LogP 3.00340
Index of Refraction 1.524

 Synonyms

AK 295
Cbz-leu-abu-conh(CH2)3-mpl
CX 295
Cbz-leu-aminobutyrate-conh(CH2)3-morpholine
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