CEM114

Modify Date: 2024-01-16 13:34:58

CEM114 Structure
CEM114 structure
Common Name CEM114
CAS Number 2279062-54-1 Molecular Weight 1612.98
Density N/A Boiling Point N/A
Molecular Formula C84H122FN9O19S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CEM114


CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].

 Names

Name CEM114

 CEM114 Biological Activity

Description CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].
Related Catalog
In Vitro CEM114 (200 nM; 48 hours) treatment significantly activates the Green Fluorescent Protein (GFP) signal, suggesting that excess FK506 is able to outcompete CEM114 from the FKBP binding site[1]. Cell Viability Assay[1] Cell Line: HEK 293T cells Concentration: 200 nM Incubation Time: 48 hours Result: Significantly activated the GFP signal.
References

[1]. Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.

 Chemical & Physical Properties

Molecular Formula C84H122FN9O19S
Molecular Weight 1612.98
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