5-Hydroxymethyluracil-d3

Modify Date: 2024-01-31 09:01:51

5-Hydroxymethyluracil-d3 Structure
5-Hydroxymethyluracil-d3 structure
Common Name 5-Hydroxymethyluracil-d3
CAS Number 352438-73-4 Molecular Weight 145.131
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C5H3D3N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Hydroxymethyluracil-d3


5-Hydroxymethyluracil-d3 is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].

 Names

Name 5-(hydroxymethyl-d2)uracil-6-d1
Synonym More Synonyms

 5-Hydroxymethyluracil-d3 Biological Activity

Description 5-Hydroxymethyluracil-d3 is the deuterium labeled 5-Hydroxymethyluracil[1]. 5-Hydroxymethyluracil is a product of oxidative DNA damage. 5-Hydroxymethyluracil can be used as a potential epigenetic mark enhancing or inhibiting transcription with bacterial RNA polymerase[2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Djuric Z, et al. Quantitation of 5-(hydroxymethyl)uracil in DNA by gas chromatography with mass spectral detection. Chem Res Toxicol. 1991 Nov-Dec;4(6):687-91.  

[3]. Janoušková M, et al. 5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase. Chem Commun (Camb). 2017 Dec 12;53(99):13253-13255.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C5H3D3N2O3
Molecular Weight 145.131
Exact Mass 145.056671
PSA 85.95000
LogP -0.50
Index of Refraction 1.528

 Synonyms

5-uracil-6-d1
5-[Hydroxy(H)methyl]-2,4(1H,3H)-(6-H)pyrimidinedione
5-[Hydroxy(H)methyl](6-H)pyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione-6-d, 5-(hydroxymethyl-d)-